Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.35 |
| ▸ | CHRM4 known ✓ | P08173 | 1/20 | 0.35 |
| ▸ | CHRM5 known ✓ | P08912 | 1/20 | 0.35 |
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.35 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.35 |
| ▸ | SNCA | P37840 | 2/20 | 0.47 |
| ▸ | CNR2 | P34972 | 5/20 | 0.46 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.42 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | AR | P10275 | 1/20 | 0.38 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | BDKRB2 | P30411 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL13369765 | 0.91 | CNR2 (0.44) | SNCACNR2NR1H2NR1H3NPSR1 | |
| Bromide SCHEMBL1236153 | 0.84 | CNR2 (0.54) | SNCACNR2L3MBTL1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL4665616 | 0.81 | CNR2 (0.41) | SNCACNR2NR1H2NR1H3KDM4E | |
| Bromide SCHEMBL2688048 | 0.79 | SNCA (0.54) | SNCAALDH1A1BDKRB2 | |
| Bromide SCHEMBL28586393 | 0.79 | SNCA (0.58) | SNCACNR2L3MBTL1KDM4EALDH1A1 | |
| Iodide SCHEMBL10428917 | 0.78 | SNCA (0.42) | SNCACNR2 | |
| Iodide SCHEMBL27951764 | 0.78 | CNR2 (0.47) | CNR2NR1H2NR1H3NPSR1KDM4E | |
| Bromide SCHEMBL10623133 | 0.78 | SNCA (0.53) | SNCAKDM4EALDH1A1CHRM2CHRM5 | |
| Iodide SCHEMBL2015457 | 0.77 | SNCA (0.46) | SNCACNR2NR1H2NR1H3NPSR1 | |
| Bromide SCHEMBL10786925 | 0.76 | HTR2A (0.54) | SNCAKDM4EALDH1A1CHRM2CHRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7439537-B2 | Divinylfluorenes | AGFA GRAPHICS, N.V. (BE) | 2008-10-21 | — | — | US | disclosed |
| EP-1621598-B1 | Divinylfluorenes. | AGFA GRAPHICS NV (BE) | 2008-01-02 | — | — | EP | disclosed |
| US-20060022193-A1 | Divinylfluorenes | AGFA-GEVAERT (BE) | 2006-02-02 | — | — | US | disclosed |
| EP-1621598-A1 | Divinylfluorenes. | Agfa-Gevaert (BE) | 2006-02-01 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060022193-A1 | Divinylfluorenes | DNER, DLK1, TRPA1 | CHRM2 2941/4885CHRM4 2997/4885CHRM5 3328/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.