Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SNCA | P37840 | 2/20 | 0.46 |
| ▸ | CNR2 | P34972 | 7/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.39 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.37 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.36 |
| ▸ | MITF | O75030 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | NPY1R | P25929 | 1/20 | 0.36 |
| ▸ | NPY2R | P49146 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL1236153 | 0.85 | CNR2 (0.54) | SNCACNR2KMT2AMEN1TSHR | |
| Iodide SCHEMBL14763355 | 0.79 | ESR1 (0.43) | KMT2AMEN1NOX1MAPTNPSR1 | |
| SCHEMBL133939 | 0.78 | TSHR (0.55) | CNR2KMT2AMEN1NR1H2NR1H3 | |
| Iodide SCHEMBL13369765 | 0.77 | CNR2 (0.44) | SNCACNR2NR1H2NR1H3NPC1 | |
| Bromide SCHEMBL4595866 | 0.77 | SNCA (0.47) | SNCACNR2NR1H2NR1H3NPSR1 | |
| Hydrochloric Acid SCHEMBL11299552 | 0.76 | TSHR (0.53) | CNR2KMT2AMEN1NR1H2NR1H3 | |
| SCHEMBL8038944 | 0.76 | ALDH1A1 (0.50) | CNR2KMT2AMEN1NR1H2NR1H3 | |
| Hydrochloric Acid SCHEMBL10705984 | 0.74 | TSHR (0.52) | CNR2KMT2AMEN1NR1H2NR1H3 | |
| Hydrochloric Acid SCHEMBL8040784 | 0.74 | KMT2A (0.49) | CNR2KMT2AMEN1NR1H2NR1H3 | |
| SCHEMBL8039657 | 0.74 | ALDH1A1 (0.54) | CNR2KMT2AMEN1TSHRNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2513083-B1 | BIPHOTONIC PHOTOSENSITIZERS, NANOPARTICLES CONTAINING THE SAME AND THEIR USE AS DRUGS | CENTRE NAT RECH SCIENT (FR) | 2016-04-06 | — | — | EP | disclosed |
| US-8709747-B2 | Biphotonic photosensitizers, nanoparticles containing the same and their use as drugs | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2014-04-29 | — | — | US | disclosed |
| US-20130065849-A1 | BIPHOTONIC PHOTOSENSITIZERS, NANOPARTICLES CONTAINING THE SAME AND THEIR USE AS DRUGS | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2013-03-14 | — | — | US | disclosed |
| EP-2513096-A1 | SUBSTITUTED AMINOTHIAZOLONE INDAZOLES AS ESTROGEN RELATED RECEPTOR-A MODULATORS | Janssen Pharmaceutica, N.V. (BE) | 2012-10-24 | — | — | EP | disclosed |
| EP-2513083-A1 | BIPHOTONIC PHOTOSENSITIZERS, NANOPARTICLES CONTAINING THE SAME AND THEIR USE AS DRUGS | CNRS Centre National De La Recherche Scientifique (FR) | 2012-10-24 | — | — | EP | disclosed |
| WO-2011075565-A1 | SUBSTITUTED AMINOTHIAZOLONE INDAZOLES AS ESTROGEN RELATED RECEPTOR-Aα MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2011-06-23 | — | — | WO | disclosed |
| WO-2011073054-A1 | BIPHOTONIC PHOTOSENSITIZERS, NANOPARTICLES CONTAINING THE SAME AND THEIR USE AS DRUGS | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2011-06-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130065849-A1 | BIPHOTONIC PHOTOSENSITIZERS, NANOPARTICLES CONTAINING THE SAME AND THEIR USE AS DRUGS | CCNB1, ABCB1, CA6 | SNCA 1016/4885CNR2 552/4885KMT2A 1964/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.