Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1692886 | 0.84 | MEN1 (0.34) | MEN1TSHRKMT2A | |
| SCHEMBL1692646 | 0.84 | MEN1 (0.34) | MEN1TSHRKMT2A | |
| SCHEMBL4578455 | 0.80 | MEN1 (0.33) | MEN1TSHRKMT2A | |
| SCHEMBL2640272 | 0.80 | TERT (0.31) | MEN1TSHRKMT2A | |
| SCHEMBL2640238 | 0.80 | TERT (0.31) | MEN1TSHRKMT2A | |
| SCHEMBL4969704 | 0.79 | — | — | |
| SCHEMBL1516369 | 0.77 | MEN1 (0.32) | MEN1TSHRKMT2A | |
| SCHEMBL4595854 | 0.74 | — | — | |
| SCHEMBL4577634 | 0.71 | — | — | |
| SCHEMBL4577380 | 0.71 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1874768-A2 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2008-01-09 | — | — | EP | disclosed |
| WO-2006113837-A2 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2006-10-26 | — | — | WO | disclosed |