Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.37 |
| ▸ | CPA1 | P15085 | 1/20 | 0.37 |
| ▸ | CES1 | P23141 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6686346 | 0.74 | EPHX1 (0.45) | EPHX1LMNASMN1; SMN2L3MBTL1POLB | |
| SCHEMBL820641 | 0.74 | CYP2C19 (0.45) | EPHX1LMNASMN1; SMN2L3MBTL1POLB | |
| SCHEMBL5902536 | 0.71 | EPHX1 (0.42) | EPHX1LMNASMN1; SMN2L3MBTL1POLB | |
| SCHEMBL2311192 | 0.71 | EPHX1 (0.66) | EPHX1LMNASMN1; SMN2L3MBTL1PKM | |
| SCHEMBL27618189 | 0.70 | MEN1 (0.43) | LMNASMN1; SMN2CES1CYP2C19CYP1A2 | |
| SCHEMBL11371564 | 0.70 | FFAR1 (0.39) | LMNASMN1; SMN2L3MBTL1POLBMAPK1 | |
| SCHEMBL6796251 | 0.69 | EPHX1 (0.71) | EPHX1LMNASMN1; SMN2L3MBTL1POLB | |
| SCHEMBL8659778 | 0.69 | POLB (0.46) | LMNASMN1; SMN2L3MBTL1POLBMAPK1 | |
| SCHEMBL585643 | 0.69 | SMN1; SMN2 (0.39) | LMNASMN1; SMN2L3MBTL1POLBMAPK1 | |
| SCHEMBL1483540 | 0.68 | EPHX1 (0.46) | EPHX1LMNASMN1; SMN2L3MBTL1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008100621-A2 | TETRAHYDRO-PYRAZOLO-PYRIDINE THIOETHER MODULATORS OF CATHEPSIN S | SUNESIS PHARMACEUTICALS, INC. (US) | 2008-08-21 | — | — | WO | disclosed |