Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 2/20 | 0.39 |
| ▸ | ULK1 | O75385 | 2/20 | 0.33 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.33 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.31 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.31 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.31 |
| ▸ | AKT1 | P31749 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4896287 | 0.82 | KIF11 (0.45) | KIF11PDE3BPDE3AALDH1A1POLB | |
| SCHEMBL4893622 | 0.78 | KIF11 (0.47) | KIF11CYP11B1CYP11B2 | |
| SCHEMBL3310186 | 0.73 | KIF11 (0.70) | KIF11ULK1PDE3BPDE3AALDH1A1 | |
| SCHEMBL4596297 | 0.72 | KIF11 (0.55) | KIF11PDE3BPDE3AALDH1A1POLB | |
| SCHEMBL4894920 | 0.72 | KIF11 (0.49) | KIF11PDE3BPDE3AALDH1A1POLB | |
| SCHEMBL4888989 | 0.70 | KIF11 (0.68) | KIF11ULK1PDE3BPDE3AALDH1A1 | |
| SCHEMBL4595128 | 0.70 | KIF11 (0.50) | KIF11CYP11B1CYP11B2 | |
| SCHEMBL4595996 | 0.70 | KIF11 (0.47) | KIF11ULK1PDE3BPDE3AAKT1 | |
| SCHEMBL4596463 | 0.67 | KIF11 (0.59) | KIF11PDE3BPDE3AMAPTCYP1A2 | |
| SCHEMBL4608672 | 0.67 | KIF11 (0.46) | KIF11PDE3BPDE3AALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1874753-A2 | COMPOUNDS, COMPOSITIONS AND METHODS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-01-09 | — | — | EP | claimed |
| WO-2006113432-A2 | COMPOUNDS, COMPOSITIONS AND METHODS | SMITHKLINE BEECHAM CORPORATION (US) | 2006-10-26 | — | — | WO | claimed |