Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4596269 | 1.00 | LMNA (0.44) | LMNAALDH1A1RIPK1 | |
| SCHEMBL27995284 | 0.83 | LMNA (0.40) | LMNAALDH1A1 | |
| SCHEMBL5069168 | 0.82 | LMNA (0.48) | LMNAALDH1A1 | |
| SCHEMBL5069171 | 0.82 | LMNA (0.48) | LMNAALDH1A1 | |
| SCHEMBL4622794 | 0.82 | LMNA (0.48) | LMNAALDH1A1 | |
| SCHEMBL5067551 | 0.82 | LMNA (0.48) | LMNAALDH1A1 | |
| SCHEMBL28194949 | 0.79 | KLK7 (0.45) | LMNAALDH1A1RIPK1 | |
| SCHEMBL1843454 | 0.79 | KLK7 (0.45) | LMNAALDH1A1RIPK1 | |
| SCHEMBL29997863 | 0.79 | KLK7 (0.45) | LMNAALDH1A1RIPK1 | |
| SCHEMBL13997813 | 0.79 | KLK7 (0.45) | LMNAALDH1A1RIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1874768-A2 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2008-01-09 | — | — | EP | disclosed |
| WO-2006113837-A2 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2006-10-26 | — | — | WO | disclosed |