Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.47 |
| ▸ | SLC6A1 | P30531 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5067551 | 1.00 | LMNA (0.48) | LMNASLC6A9SLC6A1ALDH1A1 | |
| SCHEMBL4622794 | 1.00 | LMNA (0.48) | LMNASLC6A9SLC6A1ALDH1A1 | |
| SCHEMBL5069168 | 1.00 | LMNA (0.48) | LMNASLC6A9SLC6A1ALDH1A1 | |
| SCHEMBL4596099 | 0.82 | LMNA (0.44) | LMNAALDH1A1 | |
| SCHEMBL4596269 | 0.82 | LMNA (0.44) | LMNAALDH1A1 | |
| SCHEMBL11311855 | 0.81 | SLC6A1 (0.45) | LMNASLC6A1 | |
| SCHEMBL11309797 | 0.81 | KDM4E (0.47) | — | |
| SCHEMBL4589105 | 0.78 | LMNA (0.49) | LMNA | |
| SCHEMBL3540440 | 0.77 | DPP4 (0.46) | LMNAALDH1A1 | |
| SCHEMBL5177302 | 0.77 | DPP4 (0.46) | LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080318947-A1 | Inhibitors of Akt Activity | HEERDING DIRK A | 2008-12-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080318947-A1 | Inhibitors of Akt Activity | PI4KB, PIK3CA, AKT2 | LMNA 3066/4885SLC6A9 4727/4885SLC6A1 4856/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.