Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP8 | P22894 | 1/20 | 0.39 |
| ▸ | FPR2 | P25090 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4595956 | 1.00 | MMP8 (0.39) | MMP8FPR2CYP2D6CYP2C19 | |
| SCHEMBL2447756 | 0.85 | — | — | |
| SCHEMBL15454398 | 0.76 | CNR2 (0.38) | MMP8FPR2CYP2D6CYP2C19 | |
| SCHEMBL1692813 | 0.73 | KDM4E (0.31) | — | |
| SCHEMBL23168321 | 0.73 | CYP2C19 (0.41) | MMP8FPR2CYP2D6CYP2C19 | |
| SCHEMBL5194246 | 0.72 | PIK3CD (0.34) | MMP8CYP2D6CYP2C19 | |
| SCHEMBL4594988 | 0.72 | PIK3CD (0.34) | MMP8CYP2D6CYP2C19 | |
| SCHEMBL4972011 | 0.72 | CHRM5 (0.40) | MMP8 | |
| SCHEMBL4659547 | 0.72 | — | — | |
| SCHEMBL1692666 | 0.70 | KDM4E (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1874768-A2 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2008-01-09 | — | — | EP | disclosed |
| WO-2006113837-A2 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2006-10-26 | — | — | WO | disclosed |