Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C2 | P08235 | 3/20 | 0.40 |
| ▸ | KIF11 | P52732 | 1/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.37 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.35 |
| ▸ | KCNJ1 | P48048 | 2/20 | 0.35 |
| ▸ | PGR | P06401 | 7/20 | 0.35 |
| ▸ | CTSC | P53634 | 2/20 | 0.34 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.34 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.34 |
| ▸ | OTUD7B | Q6GQQ9 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4596597 | 0.79 | KIF11 (0.44) | KIF11CYP11B1CYP11B2CTSCPDE3B | |
| SCHEMBL4596356 | 0.79 | KIF11 (0.57) | KIF11CYP11B1CYP11B2PGRPDE3B | |
| SCHEMBL4890586 | 0.78 | KIF11 (0.58) | KIF11CYP11B1CYP11B2PDE3BPDE3A | |
| SCHEMBL4897471 | 0.76 | CYP11B1 (0.56) | NR3C2KIF11CYP11B1CYP11B2PGR | |
| SCHEMBL3306017 | 0.74 | KIF11 (0.62) | KIF11CYP11B1CYP11B2PGRCTSC | |
| SCHEMBL4891714 | 0.71 | KIF11 (0.49) | KIF11CYP11B1CYP11B2PGRPDE3B | |
| SCHEMBL3307911 | 0.71 | KIF11 (0.58) | KIF11CYP11B1CYP11B2PGRPDE3B | |
| SCHEMBL4259454 | 0.67 | PDE3B (0.49) | NR3C2PGRPDE3BPDE3AALDH1A1 | |
| SCHEMBL8192358 | 0.67 | CYP11B1 (0.48) | NR3C2KIF11CYP11B1CYP11B2PDE3B | |
| SCHEMBL474617 | 0.65 | NR3C2 (0.51) | NR3C2PGRALDH1A1MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1874753-A2 | COMPOUNDS, COMPOSITIONS AND METHODS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-01-09 | — | — | EP | claimed |
| WO-2006113432-A2 | COMPOUNDS, COMPOSITIONS AND METHODS | SMITHKLINE BEECHAM CORPORATION (US) | 2006-10-26 | — | — | WO | claimed |