Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 6/20 | 0.44 |
| ▸ | CTSC | P53634 | 3/20 | 0.36 |
| ▸ | AKT1 | P31749 | 1/20 | 0.34 |
| ▸ | MMP8 | P22894 | 1/20 | 0.34 |
| ▸ | MMP13 | P45452 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.32 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.32 |
| ▸ | RORC | P51449 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.31 |
| ▸ | DRD3 | P35462 | 1/20 | 0.31 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.31 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.31 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.31 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.31 |
| ▸ | DPP4 | P27487 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4596456 | 0.79 | NR3C2 (0.40) | KIF11CTSCPDE3BPDE3ACYP11B1 | |
| SCHEMBL4891219 | 0.74 | KIF11 (0.56) | KIF11AKT1OPRK1DRD3PDE3B | |
| SCHEMBL4890586 | 0.71 | KIF11 (0.58) | KIF11PDE3BPDE3ACYP11B1CYP11B2 | |
| SCHEMBL4897471 | 0.70 | CYP11B1 (0.56) | KIF11PDE3BPDE3ACYP11B1CYP11B2 | |
| SCHEMBL4596430 | 0.70 | KIF11 (0.59) | KIF11OPRK1TRPV1PDE3BPDE3A | |
| SCHEMBL3467252 | 0.68 | KIF11 (0.53) | KIF11AKT1PDE3BPDE3A | |
| SCHEMBL3306017 | 0.68 | KIF11 (0.62) | KIF11CTSCPDE3BPDE3ACYP11B1 | |
| SCHEMBL1396616 | 0.67 | KIF11 (1.00) | KIF11AKT1PDE3BPDE3ACYP11B1 | |
| SCHEMBL4891714 | 0.65 | KIF11 (0.49) | KIF11PDE3BPDE3ACYP11B1CYP11B2 | |
| SCHEMBL3308412 | 0.65 | KIF11 (0.53) | KIF11AKT1RORCPDE3BPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1874753-A2 | COMPOUNDS, COMPOSITIONS AND METHODS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-01-09 | — | — | EP | disclosed |
| WO-2006113432-A2 | COMPOUNDS, COMPOSITIONS AND METHODS | SMITHKLINE BEECHAM CORPORATION (US) | 2006-10-26 | — | — | WO | disclosed |