Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 5/20 | 0.37 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 4/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | BCL6 | P41182 | 1/20 | 0.30 |
| ▸ | BCOR | Q6W2J9 | 1/20 | 0.30 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.30 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.30 |
| ▸ | PKLR | P30613 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4595080 | 0.86 | KIF11 (0.40) | KIF11CYP11B1CYP11B2PKMPKLR | |
| SCHEMBL4595991 | 0.74 | CYP11B1 (0.56) | KIF11CYP11B1CYP11B2 | |
| SCHEMBL4596019 | 0.74 | KIF11 (0.44) | KIF11PKMMAPTPDE3BPDE3A | |
| SCHEMBL4596372 | 0.73 | KIF11 (0.62) | KIF11CYP11B1CYP11B2PKMMAPT | |
| SCHEMBL4896686 | 0.71 | CYP11B1 (0.51) | KIF11CYP11B1CYP11B2PDE3BPDE3A | |
| SCHEMBL4898364 | 0.70 | CYP11B1 (0.52) | KIF11CYP11B1CYP11B2PDE3BPDE3A | |
| SCHEMBL4595128 | 0.70 | KIF11 (0.50) | KIF11CYP11B1CYP11B2 | |
| SCHEMBL4596680 | 0.70 | KIF11 (0.68) | KIF11CYP11B1CYP11B2PKMMAPT | |
| SCHEMBL4890959 | 0.70 | KIF11 (0.68) | KIF11CYP11B1CYP11B2PKMMAPT | |
| SCHEMBL3310186 | 0.69 | KIF11 (0.70) | KIF11CYP11B1CYP11B2MAPTPDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1874753-A2 | COMPOUNDS, COMPOSITIONS AND METHODS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-01-09 | — | — | EP | claimed |
| WO-2006113432-A2 | COMPOUNDS, COMPOSITIONS AND METHODS | SMITHKLINE BEECHAM CORPORATION (US) | 2006-10-26 | — | — | WO | claimed |