Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 8/20 | 0.44 |
| ▸ | PKM | P14618 | 3/20 | 0.34 |
| ▸ | PKLR | P30613 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.32 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.32 |
| ▸ | AKT1 | P31749 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.31 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | RORC | P51449 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4596524 | 0.74 | KIF11 (0.37) | KIF11PKMPKLRMAPTPDE3B | |
| SCHEMBL4896686 | 0.73 | CYP11B1 (0.51) | KIF11PDE3BPDE3A | |
| SCHEMBL4596493 | 0.73 | NOTUM (0.47) | KIF11MAPTPDE3BPDE3A | |
| SCHEMBL4594863 | 0.72 | KIF11 (0.39) | KIF11PDE3BPDE3ARORC | |
| SCHEMBL4649795 | 0.72 | KIF11 (0.46) | KIF11MAPTAKT1PTGS2 | |
| SCHEMBL4898364 | 0.72 | CYP11B1 (0.52) | KIF11PDE3BPDE3A | |
| SCHEMBL4596680 | 0.72 | KIF11 (0.68) | KIF11PKMPKLRMAPTPDE3B | |
| SCHEMBL4890586 | 0.71 | KIF11 (0.58) | KIF11PKMMAPTPDE3BPDE3A | |
| SCHEMBL3310186 | 0.71 | KIF11 (0.70) | KIF11MAPTPDE3BPDE3A | |
| SCHEMBL4596143 | 0.71 | KIF11 (0.66) | KIF11MAPTPDE3BPDE3AAKT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1874753-A2 | COMPOUNDS, COMPOSITIONS AND METHODS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-01-09 | — | — | EP | claimed |
| WO-2006113432-A2 | COMPOUNDS, COMPOSITIONS AND METHODS | SMITHKLINE BEECHAM CORPORATION (US) | 2006-10-26 | — | — | WO | claimed |