Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 4/20 | 0.37 |
| ▸ | P2RX4 | Q99571 | 4/20 | 0.36 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.36 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.36 |
| ▸ | SLC6A1 | P30531 | 1/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 4/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.34 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | HRH1 | P35367 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1861404 | 0.87 | KMT2A (0.36) | ALOX5P2RX4P2RX1P2RX3SLC6A1 | |
| SCHEMBL7599789 | 0.81 | ALOX5 (0.32) | ALOX5P2RX4P2RX1P2RX3SLC6A1 | |
| SCHEMBL27546411 | 0.79 | CHRM3 (0.39) | ALOX5P2RX4CHRM3LMNA | |
| SCHEMBL3641456 | 0.79 | ALOX5 (0.39) | ALOX5P2RX4P2RX1P2RX3CHRM3 | |
| Bromomethane SCHEMBL28363986 | 0.77 | P2RX4 (0.33) | ALOX5P2RX4P2RX1P2RX3 | |
| SCHEMBL3890644 | 0.77 | ALOX5 (0.38) | ALOX5P2RX4CHRM3CHRM2CHRM1 | |
| SCHEMBL523372 | 0.75 | ALOX5 (0.39) | ALOX5P2RX4P2RX1P2RX3SLC6A1 | |
| Bromide SCHEMBL27743791 | 0.74 | ALOX5 (0.38) | ALOX5P2RX4P2RX1P2RX3SLC6A1 | |
| SCHEMBL29556345 | 0.71 | ALOX5 (0.39) | ALOX5P2RX4CHRM3CYP2C9ATM | |
| SCHEMBL6973661 | 0.71 | ALOX5 (0.39) | ALOX5P2RX4CHRM3CYP2C9ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104024244-A | Heterocyclic compounds, medicaments containing said compounds, their use and processes for their preparation | BOEHRINGER INGELHEIM INT | 2014-09-03 | — | — | CN | disclosed |
| EP-1877376-A1 | NOVEL COMPOUNDS FOR TREATING INFLAMMATORY DISEASES | Boehringer Ingelheim International GmbH (DE) | 2008-01-16 | — | — | EP | disclosed |
| EP-1874781-A1 | DIHYDROTHIENOPYRIMIDINES FOR THE TREATMENT OF INFLAMMATORY DISEASES | Boehringer Ingelheim International GmbH (DE) | 2008-01-09 | — | — | EP | disclosed |
| WO-2006114371-A1 | NOVEL COMPOUNDS FOR TREATING INFLAMMATORY DISEASES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2006-11-02 | — | — | WO | disclosed |
| WO-2006111549-A1 | DIHYDROTHIENOPYRIMIDINES FOR THE TREATMENT OF INFLAMMATORY DISEASES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2006-10-26 | — | — | WO | disclosed |