Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | CTSD | P07339 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4664295 | 0.98 | NR1H4 (0.37) | NR1H4KMT2AATMCTSD | |
| SCHEMBL3834127 | 0.96 | NR1H4 (0.38) | NR1H4KMT2AATMCTSD | |
| SCHEMBL4620344 | 0.94 | CTSD (0.34) | NR1H4CTSD | |
| SCHEMBL3836011 | 0.93 | NR1H4 (0.34) | NR1H4CTSD | |
| SCHEMBL4617929 | 0.92 | NR1H4 (0.36) | NR1H4KMT2AATM | |
| SCHEMBL3832238 | 0.90 | KMT2A (0.39) | NR1H4KMT2AATM | |
| SCHEMBL5709100 | 0.89 | NR1H4 (0.40) | NR1H4KMT2AATM | |
| SCHEMBL14895745 | 0.89 | NR1H4 (0.33) | NR1H4CTSD | |
| SCHEMBL4616597 | 0.89 | NR1H4 (0.43) | NR1H4KMT2AATM | |
| SCHEMBL3832617 | 0.88 | NR1H4 (0.39) | NR1H4KMT2AATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1896408-A1 | NEW 2-AZETIDINONE DERIVATIVES FOR THE TREATMENT OF HYPERLIPIDAEMIC DISEASES | AstraZeneca AB (SE) | 2008-03-12 | — | — | EP | disclosed |
| EP-1877373-A2 | BIPHENYLAZETIDINONE CHOLESTEROL ABSORPTION INHIBITORS | Microbia, Inc. (US) | 2008-01-16 | — | — | EP | disclosed |
| WO-2007051995-A2 | TERT-BUTYLAMMONIUM SALT OR ADAMNTYLAMMONIUM SALT OF ORTHO-SUBSTITUTED BENZOIC ACID DERIVATIVES | ASTRAZENECA AB (SE) | 2007-05-10 | — | — | WO | disclosed |
| WO-2006137794-A1 | NEW2-AZETIDINONE DERIVATIVES FOR THE TREATMENT OF HYPERLIPIDAEMIC DISEASES | ASTRAZENECA AB (SE) | 2006-12-28 | — | — | WO | disclosed |
| WO-2006121861-A2 | BIPHENYLAZETIDINONE CHOLESTEROL ABSORPTION INHIBITORS | MICROBIA, INC. (US) | 2006-11-16 | — | — | WO | disclosed |