Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 6/20 | 0.43 |
| ▸ | RAB9A | P51151 | 6/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | GRM5 | P41594 | 1/20 | 0.42 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.42 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.42 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | PRKCI | P41743 | 6/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6700175 | 1.00 | TSHR (0.47) | TSHRNPC1RAB9ASMN1; SMN2GRM5 | |
| Bromide SCHEMBL6703034 | 0.98 | TSHR (0.46) | TSHRNPC1RAB9ASMN1; SMN2GRM5 | |
| Hydrochloric Acid SCHEMBL6704096 | 0.98 | TSHR (0.46) | TSHRNPC1RAB9ASMN1; SMN2GRM5 | |
| SCHEMBL6696601 | 0.92 | TSHR (0.47) | TSHRNPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL12890455 | 0.76 | TSHR (0.54) | TSHRNPC1RAB9ASMN1; SMN2GRM5 | |
| SCHEMBL2903952 | 0.76 | RAB9A (0.50) | TSHRNPC1RAB9ASMN1; SMN2GRM5 | |
| SCHEMBL6700167 | 0.73 | TSHR (0.62) | TSHRNPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL19990184 | 0.72 | TSHR (0.57) | TSHRNPC1RAB9ASMN1; SMN2GRM5 | |
| SCHEMBL10893635 | 0.72 | APOBEC3A (0.53) | TSHRNPC1RAB9ASMN1; SMN2GRM5 | |
| SCHEMBL24741297 | 0.71 | RAB9A (0.45) | TSHRNPC1RAB9ASMN1; SMN2GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1878731-B1 | Process for producing pramipexole | HELM AG (DE) | 2008-08-20 | — | — | EP | disclosed |
| EP-1878731-A1 | Process for producing pramipexole | Helm AG (DE) | 2008-01-16 | — | — | EP | disclosed |