Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 6/20 | 0.40 |
| ▸ | BRD4 | O60885 | 5/20 | 0.36 |
| ▸ | CREBBP | Q92793 | 4/20 | 0.36 |
| ▸ | HTR1A | P08908 | 3/20 | 0.36 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.34 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.34 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.34 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.34 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.34 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.34 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | TNKS | O95271 | 1/20 | 0.33 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4596609 | 0.89 | PARP1 (0.38) | PARP1BRD4CREBBPHTR1APRKAB2 | |
| SCHEMBL4706710 | 0.87 | CNR1 (0.39) | GRM2PARP1BRD4CREBBPHTR1A | |
| SCHEMBL4649496 | 0.86 | DHODH (0.41) | GRM2PARP1NPC1RAB9A | |
| SCHEMBL4597162 | 0.82 | PRKAB2 (0.34) | GRM2PARP1HTR1APRKAB2PRKAG1 | |
| SCHEMBL4596424 | 0.82 | PARP1 (0.37) | GRM2PARP1BRD4CREBBPHTR1A | |
| SCHEMBL4218780 | 0.79 | PRKAB2 (0.57) | GRM2PRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL4596976 | 0.79 | PARP1 (0.44) | GRM2PARP1BRD4HTR1ANPC1 | |
| SCHEMBL4235876 | 0.79 | AQP1 (0.52) | GRM2PRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL4709866 | 0.78 | PARP1 (0.39) | GRM2PARP1BRD4CREBBPHTR1A | |
| SCHEMBL4595107 | 0.78 | PARP1 (0.42) | GRM2PARP1HTR1AHTR2CTNKS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1874750-A1 | DIHYDROBENZOFURANYL ALKANAMINE DERIVATIVES AS 5HT2C AGONISTS | Wyeth Incoporated (US) | 2008-01-09 | — | — | EP | disclosed |
| WO-2007030150-A1 | DIHYDROBENZOFURANYL ALKANAMINE DERIVATIVES AS 5HT2C AGONISTS | WYETH (US) | 2007-03-15 | — | — | WO | disclosed |
| EP-1675840-A1 | DIHYDROBENZOFURANYL ALKANAMINE DERIVATIVES AS 5HT2C AGONISTS | Wyeth a Corporation of the State of Delaware (US) | 2006-07-05 | — | — | EP | disclosed |
| WO-2005044812-A1 | DIHYDROBENZOFURANYL ALKANAMINE DERIVATIVES AS 5HT2C AGONISTS | WYETH A CORPORATION OF THE STATE OF DELAWARE (US) | 2005-05-19 | — | — | WO | disclosed |