Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT1 | P17948 | 5/20 | 0.40 |
| ▸ | FLT4 | P35916 | 5/20 | 0.40 |
| ▸ | KDR | P35968 | 5/20 | 0.40 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.40 |
| ▸ | KIT | P10721 | 5/20 | 0.39 |
| ▸ | IMPDH2 | P12268 | 5/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2341841 | 0.86 | KDR (0.50) | FLT1FLT4KDRIMPDH2MEN1 | |
| SCHEMBL544184 | 0.85 | KIT (0.46) | FLT1FLT4KDRPTPN2PTPN1 | |
| SCHEMBL544079 | 0.83 | NPC1 (0.54) | FLT1FLT4KDRKITIMPDH2 | |
| SCHEMBL14058644 | 0.79 | KDR (0.61) | FLT1FLT4KDRPTPN2PTPN1 | |
| SCHEMBL2350226 | 0.75 | RAB9A (0.58) | FLT1FLT4KDRMEN1NPC1 | |
| SCHEMBL2342462 | 0.75 | NPC1 (0.52) | FLT1FLT4KDRKITIMPDH2 | |
| SCHEMBL544406 | 0.74 | IMPDH2 (0.62) | FLT1FLT4KDRKITIMPDH2 | |
| SCHEMBL2348479 | 0.74 | FLT1 (0.46) | FLT1FLT4KDRKITIMPDH2 | |
| SCHEMBL10033766 | 0.73 | NPC1 (0.50) | FLT1FLT4KDRIMPDH2MEN1 | |
| SCHEMBL2346767 | 0.72 | IMPDH2 (0.44) | FLT1FLT4KDRKITIMPDH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1874305-A2 | SUBSTITUTED OXAZOLE DERIVATIVES AND THEIR USE AS TYROSINE KINASE INHIBITORS | AB Science (FR) | 2008-01-09 | — | — | EP | claimed |
| WO-2006106437-A2 | SUBSTITUTED OXAZOLE DERIVATIVES AND THEIR USE AS TYROSINE KINASE INHIBITORS | AB SCIENCE (FR) | 2006-10-12 | — | — | WO | claimed |