Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 7/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.39 |
| ▸ | APP | P05067 | 2/20 | 0.35 |
| ▸ | CA1 | P00915 | 2/20 | 0.35 |
| ▸ | CA2 | P00918 | 2/20 | 0.35 |
| ▸ | CA9 | Q16790 | 2/20 | 0.35 |
| ▸ | CA7 | P43166 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.32 |
| ▸ | MAOA | P21397 | 1/20 | 0.31 |
| ▸ | MAOB | P27338 | 1/20 | 0.31 |
| ▸ | IDO1 | P14902 | 1/20 | 0.31 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.31 |
| ▸ | ORAI2 | Q96SN7 | 1/20 | 0.31 |
| ▸ | ORAI3 | Q9BRQ5 | 1/20 | 0.31 |
| ▸ | TRPV6 | Q9H1D0 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5484562 | 0.85 | APP (0.42) | APPCA1CA2CA9CA12 | |
| SCHEMBL7717366 | 0.82 | GRM5 (0.50) | GRM5FFAR1APPCA1CA2 | |
| SCHEMBL10300106 | 0.82 | GRM5 (0.50) | GRM5FFAR1APPCA1CA2 | |
| SCHEMBL718949 | 0.82 | GRM5 (0.50) | GRM5FFAR1APPCA1CA2 | |
| Charcoal, Activated SCHEMBL31286307 | 0.79 | GRM5 (0.48) | GRM5FFAR1APPCA1CA2 | |
| Fluoride SCHEMBL31286313 | 0.79 | GRM5 (0.48) | GRM5FFAR1APPCA1CA2 | |
| SCHEMBL29868576 | 0.77 | GRM5 (0.42) | GRM5FFAR1APPCA1CA2 | |
| SCHEMBL29001486 | 0.76 | APP (0.47) | GRM5FFAR1APPCA1CA2 | |
| SCHEMBL20212084 | 0.74 | GRM5 (0.50) | GRM5FFAR1APPCA1CA2 | |
| SCHEMBL13810534 | 0.74 | GRM5 (0.45) | GRM5FFAR1APPCA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1877378-A2 | OXINDOLE COMPOUNDS AND THEIR USES AS THERAPEUTIC AGENTS | XENON PHARMACEUTICALS INC. (CA) | 2008-01-16 | — | — | EP | disclosed |
| WO-2006113864-A2 | OXINDOLE COMPOUNDS AND THEIR USES AS THERAPEUTIC AGENTS | XENON PHARMACEUTICALS INC. (CA) | 2006-10-26 | — | — | WO | disclosed |