Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 13/20 | 0.74 |
| ▸ | AKR1C2 | P52895 | 13/20 | 0.74 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.52 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.52 |
| ▸ | PSEN1 | P49768 | 3/20 | 0.52 |
| ▸ | PSEN2 | P49810 | 3/20 | 0.52 |
| ▸ | APH1B | Q8WW43 | 3/20 | 0.52 |
| ▸ | NCSTN | Q92542 | 3/20 | 0.52 |
| ▸ | APH1A | Q96BI3 | 3/20 | 0.52 |
| ▸ | PSENEN | Q9NZ42 | 3/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.51 |
| ▸ | APP | P05067 | 2/20 | 0.51 |
| ▸ | FABP2 | P12104 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.51 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1372793 | 0.85 | AKR1C3 (1.00) | AKR1C3AKR1C2PTGS1PTGS2PSEN1 | |
| SCHEMBL4596111 | 0.83 | AKR1C3 (0.61) | AKR1C3AKR1C2PTGS1PTGS2PSEN1 | |
| SCHEMBL2848165 | 0.82 | AKR1C3 (0.67) | AKR1C3AKR1C2PTGS1PTGS2PSEN1 | |
| SCHEMBL4597574 | 0.81 | PSEN1 (0.80) | AKR1C3AKR1C2PSEN1PSEN2APH1B | |
| SCHEMBL4597117 | 0.80 | PSEN1 (0.72) | AKR1C3AKR1C2PSEN1PSEN2APH1B | |
| SCHEMBL4597477 | 0.79 | AKR1C3 (0.56) | AKR1C3AKR1C2PTGS1PTGS2PSEN1 | |
| SCHEMBL1797371 | 0.79 | AKR1C3 (0.65) | AKR1C3AKR1C2PTGS1PTGS2PSEN1 | |
| SCHEMBL2844330 | 0.79 | AKR1C3 (0.62) | AKR1C3AKR1C2PTGS1PTGS2PSEN1 | |
| SCHEMBL4597659 | 0.79 | PSEN1 (0.61) | AKR1C3AKR1C2PSEN1PSEN2APH1B | |
| SCHEMBL2848167 | 0.79 | AKR1C3 (0.66) | AKR1C3AKR1C2PTGS1PTGS2PSEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1993120-B | Arylacetic acids and related compounds for treatment of alzheimer's disease | MERCK SHARP & DOHME BLURTON PETER | 2010-05-05 | — | — | CN | disclosed |
| US-20080300261-A1 | Arylacetic Acids and Related Compounds for Treatment of Alzheimer's Disease | MERCK SHARP & DOHME LTD. (GB) | 2008-12-04 | — | — | US | disclosed |
| EP-1773315-B1 | ARYLACETIC ACIDS AND RELATED COMPOUNDS FOR TREATMENT OF ALZHEIMER'S DISEASE | MERCK SHARP & DOHME (GB) | 2008-01-16 | — | — | EP | disclosed |
| CN-1993120-A | Arylacetic acids and related compounds for treatment of alzheimer's disease | MERCK SHARP & DOHME BLURTON PE (GB) | 2007-07-04 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080300261-A1 | Arylacetic Acids and Related Compounds for Treatment of Alzheimer's Disease | PSEN2, PSEN1, NAT1 | AKR1C3 521/4885AKR1C2 476/4885PTGS1 1855/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.