Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 1/20 | 0.56 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.56 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.56 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.56 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.56 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.56 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.56 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | DRD4 | P21917 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.44 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.44 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.44 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.44 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.44 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8135854 | 0.87 | HDAC3 (0.53) | HDAC3HDAC4HDAC7HDAC8HDAC6 | |
| SCHEMBL8135190 | 0.84 | POLB (0.50) | HDAC3HDAC4HDAC7HDAC8HDAC6 | |
| SCHEMBL8483124 | 0.84 | POLB (0.45) | HDAC3HDAC4HDAC7HDAC8HDAC6 | |
| SCHEMBL8577606 | 0.81 | POLB (0.42) | HDAC3HDAC4HDAC7HDAC8HDAC6 | |
| SCHEMBL8126858 | 0.80 | APOL1 (0.38) | POLB | |
| SCHEMBL8673587 | 0.79 | POLB (0.41) | HDAC3HDAC4HDAC7HDAC8HDAC6 | |
| SCHEMBL17729935 | 0.78 | POLB (0.38) | HDAC3HDAC4HDAC7HDAC8HDAC6 | |
| SCHEMBL6713006 | 0.76 | POLB (0.39) | HDAC3HDAC4HDAC7HDAC8HDAC6 | |
| SCHEMBL7716498 | 0.76 | PSEN1 (0.41) | HDAC3HDAC4HDAC7HDAC8HDAC6 | |
| SCHEMBL9398200 | 0.76 | HDAC3 (0.59) | HDAC3HDAC4HDAC7HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0904262-A4 | CONFORMATIONALLY RESTRICTED AROMATIC INHIBITORS OF MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN AND METHOD | BRISTOL MYERS SQUIBB CO (US) | 2000-10-04 | — | — | EP | claimed |
| EP-0904262-A1 | CONFORMATIONALLY RESTRICTED AROMATIC INHIBITORS OF MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN AND METHOD | BRISTOL-MYERS SQUIBB COMPANY (US) | 1999-03-31 | — | — | EP | claimed |
| WO-1997026240-A1 | CONFORMATIONALLY RESTRICTED AROMATIC INHIBITORS OF MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN AND METHOD | BRISTOL-MYERS SQUIBB COMPANY (US) | 1997-07-24 | — | — | WO | claimed |
| US-10934251-B2 | Process for the preparation of lomitapide | HETERO RESEARCH FOUNDATION (IN) | 2021-03-02 | — | — | US | disclosed |
| US-10934251-B2 | Process for the preparation of lomitapide | HETERO RESEARCH FOUNDATION (IN) | 2021-03-02 | — | — | US | disclosed |
| US-20200190018-A1 | Process For The Preparation of Lomitapide | HETERO RESEARCH FOUNDATION (IN) | 2020-06-18 | — | — | US | disclosed |
| US-20200190018-A1 | Process For The Preparation of Lomitapide | HETERO RESEARCH FOUNDATION (IN) | 2020-06-18 | — | — | US | disclosed |
| US-20180291773-A1 | PROCESS FOR THE PREPARATION OF LOMITAPIDE | HETERO RESEARCH FOUNDATION (IN) | 2018-10-11 | — | — | US | disclosed |
| US-10023526-B2 | Process for the preparation of lomitapide | HETERO RESEARCH FOUNDATION | 2018-07-17 | — | — | US | disclosed |
| US-10023526-B2 | Process for the preparation of lomitapide | HETERO RESEARCH FOUNDATION | 2018-07-17 | — | — | US | disclosed |
| US-10023526-B2 | Process for the preparation of lomitapide | HETERO RESEARCH FOUNDATION | 2018-07-17 | — | — | US | disclosed |
| WO-2006124713-A2 | 4-BIARYLYL-1-PHENYLAZETIDIN-2-ONES | MICROBIA, INC. (US) | 2006-11-23 | — | — | WO | disclosed |
| WO-2006122186-A2 | 1,4-DIPHENYL-3-HYDROXYALKYL-2-AZETIDINONE DERIVATIVES FOR TREATING HYPERCHOLESTROLEMIA | MICROBIA, INC. (US) | 2006-11-16 | — | — | WO | disclosed |
| WO-2006121861-A2 | BIPHENYLAZETIDINONE CHOLESTEROL ABSORPTION INHIBITORS | MICROBIA, INC. (US) | 2006-11-16 | — | — | WO | disclosed |
| WO-2006116499-A1 | 4-BIARYLYL-1-PHENYLAZETIDIN-2-ONE GLUCURONIDE DERIVATIVES FOR HYPERCHOLESTEROLEMIA | MICROBIA, INC. (US) | 2006-11-02 | — | — | WO | disclosed |
| WO-2006086562-A2 | PHENYLAZETIDINONE DERIVATIVES | MICROBIA, INC. (US) | 2006-08-17 | — | — | WO | disclosed |
| EP-0886637-A1 | INHIBITORS OF MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN AND METHOD | BRISTOL-MYERS SQUIBB COMPANY (US) | 1998-12-30 | — | — | EP | disclosed |
| EP-0886637-A4 | — | — | 1998-12-30 | — | — | EP | disclosed |
| US-H1729-H | Method for preparing compounds employing solid phase synthesis and novel linker-resin | BRISTOL-MYERS SQUIBB COMPANY (US) | 1998-05-05 | — | — | US | disclosed |
| WO-1997043257-A1 | INHIBITORS OF MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN AND METHOD | BRISTOL-MYERS SQUIBB COMPANY (US) | 1997-11-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10023526-B2 | Process for the preparation of lomitapide | LIPA, LPAR4, CETP | HDAC3 3105/4885HDAC4 2615/4885HDAC7 2532/4885 |
| US-20200190018-A1 | Process For The Preparation of Lomitapide | LIPA, LPAR4, CETP | HDAC3 3105/4885HDAC4 2615/4885HDAC7 2532/4885 |
| US-10934251-B2 | Process for the preparation of lomitapide | LIPA, LPAR4, CETP | HDAC3 3105/4885HDAC4 2615/4885HDAC7 2532/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.