Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.37 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.37 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.37 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.37 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.37 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.34 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.34 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6714576 | 0.81 | HDAC3 (0.35) | HDAC3HDAC4HDAC7HDAC8HDAC6 | |
| SCHEMBL8483124 | 0.80 | POLB (0.45) | POLBPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL8577606 | 0.79 | POLB (0.42) | POLBPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL8673587 | 0.78 | POLB (0.41) | POLBPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL4597996 | 0.76 | HDAC3 (0.56) | POLBPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL17729935 | 0.72 | POLB (0.38) | POLBPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL8574722 | 0.72 | POLB (0.37) | POLBPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL8576789 | 0.72 | POLB (0.35) | POLBPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL8574716 | 0.72 | KMT2A (0.36) | POLBPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL8576815 | 0.71 | MTTP (0.35) | POLBPSEN1PSEN2APH1BNCSTN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040023290-A1 | Novel therapeutic agents that modulate enzymatic processes | THERAVANCE BIOPHARMA R&D IP, LLC | 2004-02-05 | — | — | US | disclosed |
| US-20020028943-A1 | Multibinding inhibitors of microsomal triglyceride transferase protein | THERAVANCE BIOPHARMA R&D IP, LLC | 2002-03-07 | — | — | US | disclosed |
| US-6288234-B1 | FLUORINATED HETEROCYCLIC AMIDO AMINE COMPOUNDS AS DRUGS | ADVANCED MEDICINE, INC. | 2001-09-11 | — | — | US | disclosed |
| EP-1085846-A2 | MULTIBINDING INHIBITORS OF MICROSOMAL TRIGLYCERIDE TRANSFERASE PROTEIN | Advanced Medicine, Inc. (US) | 2001-03-28 | — | — | EP | disclosed |
| EP-0989857-A4 | NOVEL THERAPEUTIC AGENTS THAT MODULATE ENZYMATIC PROCESSES | ADVANCED MEDICINE INC (US) | 2001-01-17 | — | — | EP | disclosed |
| EP-0989857-A1 | NOVEL THERAPEUTIC AGENTS THAT MODULATE ENZYMATIC PROCESSES | Advanced Medicine, Inc. (US) | 2000-04-05 | — | — | EP | disclosed |
| WO-1999063929-A9 | MULTIBINDING INHIBITORS OF MICROSOMAL TRIGLYCERIDE TRANSFERASE PROTEIN | ADVANCED MEDICINE INC (US) | 2000-03-16 | — | — | WO | disclosed |
| WO-1999063929-A2 | MULTIBINDING INHIBITORS OF MICROSOMAL TRIGLYCERIDE TRANSFERASE PROTEIN | ADVANCED MEDICINE, INC. (US) | 1999-12-16 | — | — | WO | disclosed |
| WO-1999064037-A1 | NOVEL THERAPEUTIC AGENTS THAT MODULATE ENZYMATIC PROCESSES | ADVANCED MEDICINE, INC. (US) | 1999-12-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020028943-A1 | Multibinding inhibitors of microsomal triglyceride transferase protein | MTTP, CETP, HDLBP | POLB 2233/4885PSEN1 3384/4885PSEN2 3253/4885 |
| US-20040023290-A1 | Novel therapeutic agents that modulate enzymatic processes | RNASE1, ENGASE, ENTPD5 | POLB 1225/4885PSEN1 3976/4885PSEN2 3802/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.