Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR5 | P51681 | 6/20 | 0.45 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | STS | P08842 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.40 |
| ▸ | CTSD | P07339 | 1/20 | 0.39 |
| ▸ | CTSE | P14091 | 1/20 | 0.39 |
| ▸ | BACE1 | P56817 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4623933 | 1.00 | CCR5 (0.45) | CCR5GPR119KDM4EPKMTP53 | |
| SCHEMBL5576730 | 0.82 | GPR119 (0.45) | CCR5GPR119KDM4EPKMTP53 | |
| SCHEMBL5576732 | 0.82 | GPR119 (0.45) | CCR5GPR119KDM4EPKMTP53 | |
| SCHEMBL5575457 | 0.82 | GPR119 (0.45) | CCR5GPR119KDM4EPKMTP53 | |
| SCHEMBL5575448 | 0.82 | GPR119 (0.45) | CCR5GPR119KDM4EPKMTP53 | |
| SCHEMBL5576650 | 0.81 | CCR5 (0.52) | CCR5GPR119KDM4EPKMTP53 | |
| SCHEMBL4597618 | 0.81 | CCR5 (0.57) | CCR5GPR119KDM4EPKMUSP30 | |
| SCHEMBL4597329 | 0.81 | CCR5 (0.52) | CCR5GPR119KDM4EPKMTP53 | |
| SCHEMBL5576348 | 0.81 | CCR5 (0.57) | CCR5GPR119KDM4EPKMUSP30 | |
| SCHEMBL5576545 | 0.81 | GPR119 (0.47) | CCR5GPR119KDM4EPKMJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1924265-A2 | CHEMOKINE RECEPTOR BINDING COMPOUNDS | Genzyme Corporation (US) | 2008-05-28 | — | — | EP | disclosed |
| WO-2007022371-A2 | CHEMOKINE RECEPTOR BINDING COMPOUNDS | GENZYME CORPORATION (US) | 2007-02-22 | — | — | WO | disclosed |