Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.42 |
| ▸ | CHRM5 | P08912 | 4/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.39 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.37 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.37 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | YAP1 | P46937 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4597030 | 0.90 | ESR2 (0.40) | NR1H2CHRM5CHRM1CHRM2CHRM4 | |
| SCHEMBL9350724 | 0.84 | GPR119 (0.47) | NR1H2CHRM5CHRM1CHRM2CHRM4 | |
| SCHEMBL1750511 | 0.83 | ESR2 (0.53) | NR1H2CHRM5CHRM1CHRM2CHRM4 | |
| SCHEMBL9350854 | 0.82 | DDB1 (0.39) | NR1H2CHRM5CHRM1CHRM2CHRM4 | |
| SCHEMBL5274358 | 0.81 | NR1H2 (0.45) | NR1H2CHRM5CHRM1CHRM2CHRM4 | |
| SCHEMBL1750649 | 0.80 | CHRM5 (0.48) | CHRM5CHRM1CHRM2CHRM4CHRM3 | |
| SCHEMBL951478 | 0.80 | NR1H2 (0.47) | NR1H2CHRM5CHRM1CHRM2CHRM4 | |
| SCHEMBL3197517 | 0.80 | SLC6A3 (0.54) | NR1H2CHRM5CHRM1CHRM2CHRM4 | |
| SCHEMBL6418231 | 0.79 | CHRM5 (0.59) | NR1H2CHRM5CHRM1CHRM2CHRM4 | |
| SCHEMBL5941814 | 0.77 | CHRM5 (0.45) | NR1H2CHRM5CHRM1CHRM2CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1908471-A1 | Tetrahydropyridines as renin inhibitors | Speedel Experimenta AG (CH) | 2008-04-09 | — | — | EP | disclosed |