Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.67 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.62 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.62 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.57 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.51 |
| ▸ | ABL1 | P00519 | 2/20 | 0.50 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.50 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.50 |
| ▸ | DDR1 | Q08345 | 2/20 | 0.49 |
| ▸ | BCR | P11274 | 1/20 | 0.49 |
| ▸ | HTR2C | P28335 | 1/20 | 0.49 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.49 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.48 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.48 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13753114 | 0.84 | ALDH1A1 (0.64) | NAMPTHDAC3HDAC1MCHR1GPR139 | |
| SCHEMBL13702288 | 0.81 | GPR139 (0.60) | NAMPTHDAC3HDAC1MCHR1GPR139 | |
| SCHEMBL3707857 | 0.81 | NAMPT (1.00) | NAMPTHDAC3HDAC1 | |
| SCHEMBL5481576 | 0.80 | NAMPT (0.61) | NAMPTHDAC3HDAC1MCHR1POLB | |
| SCHEMBL9159770 | 0.79 | KMT2A (0.52) | NAMPTPOLBGAAMAPTSMN1; SMN2 | |
| SCHEMBL679553 | 0.79 | KAT6A (0.58) | NAMPTHDAC3HDAC1MCHR1GPR139 | |
| SCHEMBL31180472 | 0.79 | KAT6A (0.58) | NAMPTHDAC3HDAC1MCHR1GPR139 | |
| SCHEMBL18620677 | 0.78 | GPR139 (0.55) | NAMPTHDAC3HDAC1MCHR1GPR139 | |
| SCHEMBL22753368 | 0.78 | GPR139 (0.58) | NAMPTHDAC3HDAC1MCHR1GPR139 | |
| SCHEMBL14528870 | 0.78 | GPR139 (0.61) | NAMPTHDAC3HDAC1MCHR1GPR139 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008065500-A2 | HETEROARYL AMIDES AS TYPE I GLYCINE TRANSPORT INHIBITORS | PFIZER PRODUCTS INC. (US) | 2008-06-05 | — | — | WO | disclosed |