Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.70 |
| ▸ | MAPT | P10636 | 9/20 | 0.67 |
| ▸ | RAB9A | P51151 | 7/20 | 0.67 |
| ▸ | NPC1 | O15118 | 6/20 | 0.67 |
| ▸ | MEN1 | O00255 | 4/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.67 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.67 |
| ▸ | VCP | P55072 | 2/20 | 0.67 |
| ▸ | ESR1 | P03372 | 1/20 | 0.67 |
| ▸ | POLB | P06746 | 1/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.65 |
| ▸ | HTT | P42858 | 3/20 | 0.65 |
| ▸ | LMNA | P02545 | 3/20 | 0.65 |
| ▸ | GAA | P10253 | 3/20 | 0.65 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.65 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.61 |
| ▸ | CLK1 | P49759 | 1/20 | 0.61 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.58 |
| ▸ | AMY1A | P0DUB6 | 2/20 | 0.55 |
| ▸ | USP2 | O75604 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1818950 | 0.84 | SMN1; SMN2 (0.91) | SMN1; SMN2MAPTRAB9ANPC1MEN1 | |
| SCHEMBL1886135 | 0.83 | SMN1; SMN2 (1.00) | SMN1; SMN2MAPTRAB9ANPC1MEN1 | |
| SCHEMBL27810995 | 0.80 | MAPK1 (0.75) | SMN1; SMN2MAPTRAB9ANPC1MEN1 | |
| SCHEMBL12639816 | 0.80 | MAPT (0.97) | SMN1; SMN2MAPTRAB9ANPC1MEN1 | |
| SCHEMBL1882991 | 0.80 | VCP (1.00) | SMN1; SMN2MAPTRAB9ANPC1MEN1 | |
| SCHEMBL12297166 | 0.80 | MAPT (0.73) | SMN1; SMN2MAPTRAB9ANPC1MEN1 | |
| SCHEMBL1887335 | 0.80 | ESR1 (1.00) | SMN1; SMN2MAPTRAB9ANPC1MEN1 | |
| SCHEMBL1889024 | 0.80 | MAPT (1.00) | SMN1; SMN2MAPTRAB9ANPC1MEN1 | |
| SCHEMBL1886814 | 0.80 | RAB9A (1.00) | SMN1; SMN2MAPTRAB9ANPC1MEN1 | |
| SCHEMBL12297438 | 0.80 | MAPT (0.73) | SMN1; SMN2MAPTRAB9ANPC1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1908466-B1 | SUBSTITUTED PROPANAMIDE DERIVATIVE AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME | DAIICHI SANKYO CO LTD (JP) | 2014-02-19 | — | — | EP | disclosed |
| EP-1908466-A1 | SUBSTITUTED PROPANAMIDE DERIVATIVE AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME | Daiichi Sankyo Company, Limited (JP) | 2008-04-09 | — | — | EP | disclosed |