Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ASAH1 | Q13510 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 9/20 | 0.49 |
| ▸ | MGAM | O43451 | 8/20 | 0.49 |
| ▸ | AMY1A | P0DUB6 | 8/20 | 0.49 |
| ▸ | SI | P14410 | 8/20 | 0.49 |
| ▸ | MGAM2 | Q2M2H8 | 8/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | F2 | P00734 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | MITF | O75030 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | F12 | P00748 | 4/20 | 0.45 |
| ▸ | MIF | P14174 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14639695 | 0.79 | GAA (0.54) | GAAMGAMAMY1ASIMGAM2 | |
| SCHEMBL2115731 | 0.78 | GAA (0.58) | ASAH1GAAMGAMAMY1ASI | |
| SCHEMBL14193247 | 0.77 | GAA (0.57) | ASAH1GAAMGAMAMY1ASI | |
| SCHEMBL10365955 | 0.75 | GAA (0.49) | GAAMGAMAMY1ASIMGAM2 | |
| SCHEMBL3944546 | 0.75 | MGAM (0.65) | ASAH1GAAMGAMAMY1ASI | |
| SCHEMBL459733 | 0.74 | GAA (0.60) | ASAH1GAAMGAMAMY1ASI | |
| SCHEMBL27397872 | 0.74 | MGAM (0.54) | ASAH1GAAMGAMAMY1ASI | |
| SCHEMBL9601344 | 0.73 | ASAH1 (0.62) | ASAH1GAAMGAMAMY1ASI | |
| SCHEMBL11490925 | 0.73 | ASAH1 (0.62) | ASAH1GAAMGAMAMY1ASI | |
| SCHEMBL27972637 | 0.73 | ASAH1 (0.62) | ASAH1GAAMGAMAMY1ASI |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1910340-A1 | INDAZOLECARBOXAMIDE DERIVATIVES AS 5HT4 RECEPTOR AGONISTS | Pfizer, Inc. (US) | 2008-04-16 | — | — | EP | disclosed |
| EP-1856110-A1 | OXYINDOLE DERIVATIVES AS 5HT4 RECEPTOR AGONISTS | Pfizer, Inc. (US) | 2007-11-21 | — | — | EP | disclosed |
| EP-1758891-A2 | BENZIMIDAZOLONE CARBOXYLIC ACID DERIVATIVES | Pfizer Japan Inc. (JP) | 2007-03-07 | — | — | EP | disclosed |
| WO-2007010390-A1 | INDAZOLECARBOXAMIDE DERIVATIVES AS 5HT4 RECEPTOR AGONISTS | PFIZER JAPAN INC. (JP) | 2007-01-25 | — | — | WO | disclosed |
| WO-2006090279-A1 | OXYINDOLE DERIVATIVES AS 5HT4 RECEPTOR AGONISTS | PFIZER JAPAN INC. (JP) | 2006-08-31 | — | — | WO | disclosed |
| WO-2005123718-A2 | BENZIMIDAZOLONE CARBOXYLIC ACID DERIVATIVES | PFIZER JAPAN INC. (JP) | 2005-12-29 | — | — | WO | disclosed |