Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.37 |
| ▸ | QPCT | Q16769 | 4/20 | 0.37 |
| ▸ | NAMPT | P43490 | 2/20 | 0.36 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.36 |
| ▸ | PRKCA | P17252 | 1/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.36 |
| ▸ | RPS6KA1 | Q15418 | 1/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.36 |
| ▸ | CSNK1G1 | Q9HCP0 | 1/20 | 0.36 |
| ▸ | MELK | Q14680 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.36 |
| ▸ | SYK | P43405 | 1/20 | 0.35 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14066740 | 0.94 | MAPKAPK2 (0.38) | MAPK1POLBMAPKAPK2AURKARPS6KB1 | |
| SCHEMBL14066741 | 0.82 | HPGD (0.38) | MAPK1POLBMAPKAPK2CYP2C9PDGFRA | |
| SCHEMBL4908818 | 0.78 | MAPKAPK2 (0.42) | MAPK1POLBMAPKAPK2QPCTNAMPT | |
| SCHEMBL4910847 | 0.77 | MAPKAPK2 (0.42) | MAPK1POLBMAPKAPK2QPCTCYP2C9 | |
| SCHEMBL4599129 | 0.76 | MAPKAPK2 (0.45) | MAPK1MAPKAPK2QPCTCYP2C9PDGFRA | |
| SCHEMBL4906181 | 0.76 | MAPKAPK2 (0.40) | MAPK1POLBMAPKAPK2QPCTCYP2C9 | |
| SCHEMBL4598396 | 0.73 | QPCT (0.49) | POLBMAPKAPK2QPCT | |
| SCHEMBL4898077 | 0.72 | MAPKAPK2 (0.37) | MAPK1MAPKAPK2CYP2C9PDGFRAPRKCA | |
| SCHEMBL4598398 | 0.71 | CXCR2 (0.41) | MAPK1MAPKAPK2CYP2C9PDGFRAPRKCA | |
| SCHEMBL4596962 | 0.71 | MAPKAPK2 (0.61) | MAPK1MAPKAPK2CYP2C9PDGFRAPRKCA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1910312-A1 | QUADRATIC ACID II DERIVATIVES | Merck Patent GmbH (DE) | 2008-04-16 | — | — | EP | claimed |
| WO-2007014608-A1 | QUADRATIC ACID II DERIVATIVES | MERCK PATENT GMBH (DE) | 2007-02-08 | — | — | WO | claimed |