Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | AR | P10275 | 1/20 | 0.48 |
| ▸ | EGFR | P00533 | 1/20 | 0.48 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.47 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.46 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.45 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL458059 | 0.83 | LMNA (0.58) | LMNAMAPTATMSMN1; SMN2NPC1 | |
| SCHEMBL458060 | 0.83 | LMNA (0.58) | LMNAMAPTATMSMN1; SMN2NPC1 | |
| SCHEMBL15053445 | 0.83 | LMNA (0.52) | LMNAMAPTATMSMN1; SMN2NPC1 | |
| SCHEMBL5434722 | 0.81 | LMNA (0.55) | LMNAMAPTATMSMN1; SMN2NPC1 | |
| SCHEMBL5434717 | 0.81 | LMNA (0.55) | LMNAMAPTATMSMN1; SMN2NPC1 | |
| SCHEMBL30071741 | 0.81 | LMNA (0.55) | LMNAMAPTATMSMN1; SMN2NPC1 | |
| SCHEMBL28300287 | 0.79 | LMNA (0.62) | LMNAMAPTATMSMN1; SMN2NPC1 | |
| SCHEMBL20446704 | 0.79 | LMNA (0.62) | LMNAMAPTATMSMN1; SMN2NPC1 | |
| SCHEMBL27681869 | 0.78 | LMNA (0.55) | LMNAMAPTATMSMN1; SMN2NPC1 | |
| SCHEMBL27681870 | 0.78 | LMNA (0.55) | LMNAMAPTATMSMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2614046-B1 | NOVEL GUANIDINE DERIVATIVES IN THE CINNAMIC SERIES | PROD CHIM AUXILIAIRES ET DE SYNTHESE (FR) | 2014-08-20 | — | — | EP | disclosed |
| EP-2614046-A1 | NOVEL GUANIDINE DERIVATIVES IN THE CINNAMIC SERIES | Produits Chimiques Auxiliaires et de Synthese (FR) | 2013-07-17 | — | — | EP | disclosed |
| WO-2012032257-A1 | NOVEL GUANIDINE DERIVATIVES IN THE CINNAMIC SERIES | PRODUITS CHIMIQUES AUXILIAIRES ET DE SYNTHESE (FR) | 2012-03-15 | — | — | WO | disclosed |