Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 6/20 | 0.62 |
| ▸ | MAPT | P10636 | 4/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.62 |
| ▸ | ATM | Q13315 | 1/20 | 0.62 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | AR | P10275 | 2/20 | 0.55 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.51 |
| ▸ | TFEB | P19484 | 1/20 | 0.50 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.49 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.49 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.49 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28300287 | 1.00 | LMNA (0.62) | LMNAMAPTSMN1; SMN2ATMMCL1 | |
| SCHEMBL29857458 | 0.89 | LMNA (0.60) | LMNAMAPTSMN1; SMN2ATMMCL1 | |
| SCHEMBL1536281 | 0.85 | PTGER1 (0.66) | LMNAMAPTSMN1; SMN2ATMKDM4E | |
| SCHEMBL11341981 | 0.85 | KDM4E (0.68) | LMNAMAPTSMN1; SMN2ATMKDM4E | |
| SCHEMBL11327707 | 0.85 | KDM4E (0.68) | LMNAMAPTSMN1; SMN2ATMKDM4E | |
| SCHEMBL1536282 | 0.85 | PTGER1 (0.66) | LMNAMAPTSMN1; SMN2ATMKDM4E | |
| SCHEMBL9716952 | 0.85 | LMNA (0.61) | LMNAMAPTSMN1; SMN2ATMKDM4E | |
| SCHEMBL16817700 | 0.85 | KDM4E (0.60) | LMNAMAPTSMN1; SMN2ATMMCL1 | |
| SCHEMBL9789403 | 0.84 | LMNA (0.66) | LMNAMAPTSMN1; SMN2ATMKDM4E | |
| SCHEMBL9789400 | 0.84 | LMNA (0.66) | LMNAMAPTSMN1; SMN2ATMKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3356356-A1 | COMPOUNDS USEFUL AS MODULATORS OF TRPM8 | Senomyx, Inc. (US) | 2018-08-08 | — | — | EP | disclosed |