Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | ALAD | P13716 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | LTA4H | P09960 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7253183 | 0.78 | — | — | |
| SCHEMBL4591911 | 0.64 | ALDH1A1 (0.39) | ALDH1A1MAPK1CYP2A6MAPTRAB9A | |
| SCHEMBL68094 | 0.63 | ALDH1A1 (0.73) | ALDH1A1MAPK1CYP2A6MAPTRAB9A | |
| SCHEMBL12302096 | 0.63 | ALDH1A1 (0.73) | ALDH1A1MAPK1CYP2A6MAPTRAB9A | |
| SCHEMBL1673427 | 0.63 | ALDH1A1 (0.73) | ALDH1A1MAPK1CYP2A6MAPTRAB9A | |
| Water SCHEMBL3824552 | 0.60 | ALDH1A1 (0.69) | ALDH1A1MAPK1CYP2A6MAPTRAB9A | |
| SCHEMBL1255210 | 0.60 | ALDH1A1 (0.69) | ALDH1A1MAPK1CYP2A6MAPTRAB9A | |
| SCHEMBL21518323 | 0.60 | ALDH1A1 (0.69) | ALDH1A1MAPK1CYP2A6MAPTRAB9A | |
| Bromide SCHEMBL29066324 | 0.60 | ALDH1A1 (0.69) | ALDH1A1MAPK1CYP2A6MAPTRAB9A | |
| Hydrogen Sulfide SCHEMBL4123828 | 0.60 | ALDH1A1 (0.69) | ALDH1A1MAPK1CYP2A6MAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1909775-A2 | FORMULATION OF RADIOPROTECTIVE ALPHA, BETA UNSATURATED ARYL SULFONES | Onconova Therapeutics, Inc. (US) | 2008-04-16 | — | — | EP | disclosed |
| WO-2007016201-A2 | FORMULATION OF RADIOPROTECTIVE α, β UNSATURATED ARYL SULFONES | ONCONOVA THERAPEUTICS, INC. (US) | 2007-02-08 | — | — | WO | disclosed |