Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.34 |
| ▸ | NPC1 | O15118 | 4/20 | 0.34 |
| ▸ | RAB9A | P51151 | 4/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.34 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.33 |
| ▸ | TP53 | P04637 | 3/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | GFER | P55789 | 1/20 | 0.32 |
| ▸ | UTRN | P46939 | 1/20 | 0.32 |
| ▸ | DAGLA | Q9Y4D2 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4757817 | 0.88 | HSD17B10 (0.38) | HSD17B10ALDH1A1MEN1KMT2ATSHR | |
| SCHEMBL220426 | 0.82 | CYP2C19 (0.45) | HSD17B10ALDH1A1MEN1KMT2ATSHR | |
| SCHEMBL10282752 | 0.78 | HSD17B10 (0.35) | HSD17B10ALDH1A1MEN1KMT2ATSHR | |
| SCHEMBL221531 | 0.76 | CYP2A6 (0.51) | HSD17B10ALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL23458516 | 0.72 | PIK3CB (0.60) | HSD17B10ALDH1A1MEN1KMT2ATSHR | |
| SCHEMBL220491 | 0.70 | CYP2C19 (0.45) | HSD17B10ALDH1A1MEN1KMT2ATSHR | |
| SCHEMBL9148638 | 0.69 | ALDH1A1 (0.63) | HSD17B10ALDH1A1MEN1KMT2ATSHR | |
| SCHEMBL30785580 | 0.67 | KDM4E (0.56) | HSD17B10ALDH1A1MEN1KMT2ATSHR | |
| SCHEMBL222248 | 0.67 | RAB9A (0.63) | HSD17B10ALDH1A1MEN1KMT2ATSHR | |
| SCHEMBL9868132 | 0.67 | KDM4E (0.56) | HSD17B10ALDH1A1MEN1KMT2ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1910384-A1 | IMIDAZO [2,1-B]THIAYOLE DERIVATIVES AS SIRTUIN MODULATING COMPOUNDS | Sirtris Pharmaceuticals, Inc. (US) | 2008-04-16 | — | — | EP | disclosed |
| WO-2007019344-A1 | IMIDAZO [2,1-B] THIAYOLE DERIVATIVES AS SIRTUIN MODULATING COMPOUNDS | SIRTRIS PHARMACEUTICALS, INC. (US) | 2007-02-15 | — | — | WO | disclosed |