Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CAD | P27708 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | NPY4R | P50391 | 7/20 | 0.36 |
| ▸ | NPY1R | P25929 | 5/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | NPY2R | P49146 | 4/20 | 0.33 |
| ▸ | NPY5R | Q15761 | 4/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.33 |
| ▸ | NOD1 | Q9Y239 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27481242 | 0.88 | CAD (0.39) | CADKMT2APOLBNPY4RNPY1R | |
| SCHEMBL27554606 | 0.88 | CAD (0.39) | CADKMT2APOLBNPY4RNPY1R | |
| SCHEMBL8019370 | 0.88 | CAD (0.39) | CADKMT2APOLBNPY4RNPY1R | |
| SCHEMBL8017621 | 0.87 | CAD (0.38) | CADKMT2APOLBNPY4RNPY1R | |
| SCHEMBL21879811 | 0.87 | KMT2A (0.42) | CADKMT2APOLBNPY4RNPY1R | |
| SCHEMBL14420415 | 0.85 | CAD (0.37) | CADKMT2APOLBNPY4RNPY1R | |
| SCHEMBL5812133 | 0.85 | SIRT6 (0.43) | CADKMT2APOLBNPY4RNPY1R | |
| SCHEMBL5812127 | 0.85 | SIRT6 (0.43) | CADKMT2APOLBNPY4RNPY1R | |
| Hydrochloric Acid SCHEMBL3700024 | 0.84 | NPY4R (0.36) | CADKMT2APOLBNPY4RNPY1R | |
| SCHEMBL26017775 | 0.84 | KMT2A (0.47) | CADKMT2APOLBNPY4RNPY1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1082112-B1 | ENDOGENOUS NITRIC OXIDE SYNTHESIS UNDER CONDITIONS OF LOW OXYGEN TENSION | NITROMED INC (US) | 2008-04-09 | — | — | EP | disclosed |
| EP-1242068-A4 | ENDOGENOUS NITRIC OXIDE SYNTHESIS UNDER CONDITIONS OF LOW OXYGEN TENSION | NITROMED INC (US) | 2007-04-25 | — | — | EP | disclosed |
| EP-1242068-A1 | ENDOGENOUS NITRIC OXIDE SYNTHESIS UNDER CONDITIONS OF LOW OXYGEN TENSION | Nitromed, Inc. (US) | 2002-09-25 | — | — | EP | disclosed |
| US-6436997-B1 | Endogenous nitric oxide synthesis under conditions of low oxygen tension | NITROMED, INC. | 2002-08-20 | — | — | US | disclosed |
| US-6277884-B1 | Treatment of sexual dysfunction with N-hydroxyguanidine compounds | NITROMED, INC. | 2001-08-21 | — | — | US | disclosed |
| WO-2001032167-A1 | ENDOGENOUS NITRIC OXIDE SYNTHESIS UNDER CONDITIONS OF LOW OXYGEN TENSION | NITROMED, INC. (US) | 2001-05-10 | — | — | WO | disclosed |
| US-4766110-A | INHIBITS ANGIOTENSIN CONVERTING ENZYME, HYPOTENSIVE AGENTS | RYAN JAMES W (US) | 1988-08-23 | — | — | US | disclosed |