Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.53 |
| ▸ | MEN1 | O00255 | 4/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | CES2 | O00748 | 3/20 | 0.53 |
| ▸ | CES1 | P23141 | 3/20 | 0.53 |
| ▸ | PTPRC | P08575 | 3/20 | 0.53 |
| ▸ | POLB | P06746 | 3/20 | 0.53 |
| ▸ | RECQL | P46063 | 3/20 | 0.53 |
| ▸ | THRB | P10828 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | APAF1 | O14727 | 2/20 | 0.53 |
| ▸ | TDP2 | O95551 | 2/20 | 0.53 |
| ▸ | BLM | P54132 | 2/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | TERT | O14746 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.53 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.53 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL5014553 | 1.00 | MAPT (0.53) | MAPTMEN1KMT2ACES2CES1 | |
| Bicarbonate SCHEMBL11246116 | 1.00 | MAPT (0.53) | MAPTMEN1KMT2ACES2CES1 | |
| Acetic Acid SCHEMBL11385294 | 0.86 | CES2 (0.50) | MAPTMEN1KMT2ACES2CES1 | |
| Benzene SCHEMBL27898037 | 0.83 | MEN1 (0.57) | MAPTMEN1KMT2ACES2CES1 | |
| SCHEMBL31290736 | 0.83 | MEN1 (0.57) | MAPTMEN1KMT2ACES2CES1 | |
| Bicarbonate SCHEMBL10531683 | 0.83 | BCAT2 (0.58) | MEN1KMT2ARECQLTHRBMAPK1 | |
| Bicarbonate SCHEMBL10341263 | 0.83 | BCAT2 (0.58) | MEN1KMT2ARECQLTHRBMAPK1 | |
| Urea SCHEMBL6255302 | 0.81 | KMT2A (0.50) | MAPTMEN1KMT2ACES2CES1 | |
| Acetone SCHEMBL27562549 | 0.81 | POLB (0.50) | MAPTMEN1KMT2ACES2CES1 | |
| Terephthalic Acid SCHEMBL9337978 | 0.81 | TSHR (0.72) | CES2CES1PTPRCSMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 67 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006027110-A1 | METHOD FOR THE PRODUCTION OF POLYCARBONATE | BAYER MATERIALSCIENCE AG (DE) | 2006-03-16 | — | — | WO | claimed |
| EP-0063634-A1 | Thermoplastic resin composition | DAINIPPON INK AND CHEMICALS, INC. (JP) | 1982-11-03 | — | — | EP | claimed |
| US-4351920-A | POLYCARBONATES, RUBBER MODIFIED STYRENE-MALEIC ANHYDRIDE COPOLYMER | DAINIPPON INK & CHEMICALS, INC. (JP) | 1982-09-28 | — | — | US | claimed |
| CN-111073167-A | Thermoplastic resin composition and resin molded article | 旭化成株式会社 | 2020-04-28 | — | — | CN | disclosed |
| CN-111019259-A | Thermoplastic resin composition and molded article | 旭化成株式会社 | 2020-04-17 | — | — | CN | disclosed |
| EP-3183026-B1 | IMPLANTS FOR LOCALIZED DRUG DELIVERY AND METHODS OF USE THEREOF | UNIV CALIFORNIA (US) | 2019-10-30 | — | — | EP | disclosed |
| EP-3183026-A1 | IMPLANTS FOR LOCALIZED DRUG DELIVERY AND METHODS OF USE THEREOF | The Regents of The University of California (US) | 2017-06-28 | — | — | EP | disclosed |
| EP-2954035-B1 | PROCESS FOR PREPARING A UREA GREASE | SHELL INT RESEARCH (NL) | 2016-12-21 | — | — | EP | disclosed |
| WO-2016028774-A1 | IMPLANTS FOR LOCALIZED DRUG DELIVERY AND METHODS OF USE THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2016-02-25 | — | — | WO | disclosed |
| US-20160002557-A1 | PROCESS FOR PREPARING A UREA GREASE | SHELL OIL COMPANY | 2016-01-07 | — | — | US | disclosed |
| EP-2954035-A1 | PROCESS FOR PREPARING A UREA GREASE | Shell Internationale Research Maatschappij B.V. (NL) | 2015-12-16 | — | — | EP | disclosed |
| EP-0488728-A1 | Flame-retardant polyester resin composition | POLYPLASTICS CO. LTD. (JP) | 1992-06-03 | — | — | EP | disclosed |
| US-5041369-A | Silver Halide, Silver Salt, Reducing Agent, Metal or Organic Dye | CANON KABUSHIKI KAISHA (JP) | 1991-08-20 | — | — | US | disclosed |
| US-5021321-A | Photothermography; antifogging agents; contrast; lamination of matrix of silver salts and reducing agent and dispersed particles of dye, polymer precursor and photoinitiator | CANON KABUSHIKI KAISHA (JP) | 1991-06-04 | — | — | US | disclosed |
| CN-1047098-A | Polyester and resin composition and moulded product thereof | POLYPLASTICS CO (JP) | 1990-11-21 | — | — | CN | disclosed |
| EP-0326424-A2 | Photosensitive composition, photosensitive material, and image forming method | CANON KABUSHIKI KAISHA (JP) | 1989-08-02 | — | — | EP | disclosed |
| CN-1030275-A | Articulated element | POLYPLASTICS CO (JP) | 1989-01-11 | — | — | CN | disclosed |
| CN-88102619-A | The thermoplastic resin composition | — | 1988-11-30 | — | — | CN | disclosed |
| EP-0063634-A1 | Thermoplastic resin composition | DAINIPPON INK AND CHEMICALS, INC. (JP) | 1982-11-03 | — | — | EP | disclosed |
| US-4351920-A | POLYCARBONATES, RUBBER MODIFIED STYRENE-MALEIC ANHYDRIDE COPOLYMER | DAINIPPON INK & CHEMICALS, INC. (JP) | 1982-09-28 | — | — | US | disclosed |