Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 11/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | SOD1 | P00441 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16654605 | 0.84 | MAOB (0.50) | MAOBALDH1A1KDM4ELMNASOD1 | |
| SCHEMBL16013810 | 0.81 | HSD17B10 (0.48) | MAOBALDH1A1KDM4ELMNASOD1 | |
| SCHEMBL1128564 | 0.79 | MAOB (0.45) | MAOBALDH1A1KMT2AMRGPRX4MAOA | |
| SCHEMBL237041 | 0.78 | KDM4E (0.51) | MAOBALDH1A1KDM4ELMNASOD1 | |
| SCHEMBL1604166 | 0.77 | KCNA3 (0.46) | ALDH1A1LMNAKMT2ARAB9AHTT | |
| SCHEMBL17287517 | 0.76 | CA1 (0.45) | MAOBALDH1A1KDM4ELMNAMAPT | |
| SCHEMBL1203917 | 0.75 | MAOB (0.60) | MAOBALDH1A1KDM4ELMNASOD1 | |
| SCHEMBL13883739 | 0.74 | MAOB (0.64) | MAOBALDH1A1KDM4ELMNASOD1 | |
| SCHEMBL17686087 | 0.74 | CHRNB2 (0.43) | — | |
| SCHEMBL7426703 | 0.73 | KDM4E (0.43) | MAOBALDH1A1KDM4ESOD1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1910308-A1 | IMIDAZOLE BASED LXR MODULATORS | Exelixis, Inc. (US) | 2008-04-16 | — | — | EP | disclosed |
| EP-1910307-A1 | PYRAZOLE BASED LXR MODULATORS | Exelixis, Inc. (US) | 2008-04-16 | — | — | EP | disclosed |
| WO-2007002563-A1 | IMIDAZOLE BASED LXR MODULATORS | EXELIXIS, INC. (US) | 2007-01-04 | — | — | WO | disclosed |
| WO-2007002559-A1 | PYRAZOLE BASED LXR MODULATORS | EXELIXIS, INC. (US) | 2007-01-04 | — | — | WO | disclosed |
| EP-1713820-A1 | SELECTIVE ESTROGEN RECEPTOR MODULATORS | ELI LILLY AND COMPANY (US) | 2006-10-25 | — | — | EP | disclosed |
| WO-2005073244-A1 | SELECTIVE ESTROGEN RECEPTOR MODULATORS | ELI LILLY AND COMPANY (US) | 2005-08-11 | — | — | WO | disclosed |