Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 5/20 | 0.65 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.65 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | CMA1 | P23946 | 1/20 | 0.31 |
| ▸ | NOS1 | P29475 | 2/20 | 0.31 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.31 |
| ▸ | DHODH | Q02127 | 1/20 | 0.31 |
| ▸ | MAT2A | P31153 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.30 |
| ▸ | SPR | P35270 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4600864 | 1.00 | CYP3A4 (0.65) | CYP3A4CYP2C9HCAR2ALDH1A1CMA1 | |
| Dimethylamine SCHEMBL4613323 | 0.97 | CYP3A4 (0.62) | CYP3A4CYP2C9HCAR2ALDH1A1CMA1 | |
| SCHEMBL4613531 | 0.96 | CYP3A4 (0.61) | CYP3A4CYP2C9HCAR2NOS1 | |
| SCHEMBL4599840 | 0.92 | CYP3A4 (0.63) | CYP3A4CYP2C9NOS1HSD17B10 | |
| SCHEMBL4601741 | 0.92 | CYP3A4 (0.63) | CYP3A4CYP2C9NOS1HSD17B10 | |
| SCHEMBL4601254 | 0.92 | CYP3A4 (0.63) | CYP3A4CYP2C9NOS1HSD17B10 | |
| SCHEMBL4601558 | 0.90 | CYP3A4 (0.61) | CYP3A4CYP2C9ALDH1A1KDM4EHSD17B10 | |
| SCHEMBL4601115 | 0.90 | CYP3A4 (0.61) | CYP3A4CYP2C9ALDH1A1KDM4EHSD17B10 | |
| SCHEMBL4599597 | 0.90 | CYP3A4 (0.61) | CYP3A4CYP2C9ALDH1A1KDM4ERIPK1 | |
| SCHEMBL4601224 | 0.90 | CYP3A4 (0.61) | CYP3A4CYP2C9ALDH1A1KDM4ERIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1718648-B1 | TRICYCLIC IMIDAZOPYRIDINES AND INTERMEDIATES FOR THE SYNTHESIS THEREOF | NYCOMED GMBH (DE) | 2008-04-23 | — | — | EP | claimed |
| EP-1718648-B1 | TRICYCLIC IMIDAZOPYRIDINES AND INTERMEDIATES FOR THE SYNTHESIS THEREOF | NYCOMED GMBH (DE) | 2008-04-23 | — | — | EP | disclosed |
| EP-1718648-A1 | TRICYCLIC IMIDAZOPYRIDINES AND INTERMEDIATES FOR THE SYNTHESIS THEREOF | Altana Pharma AG (DE) | 2006-11-08 | — | — | EP | disclosed |
| WO-2005077949-A1 | TRICYCLIC IMIDAZOPYRIDINES AND INTERMEDIATES FOR THE SYNTHESIS THEREOF | ALTANA PHARMA AG (DE) | 2005-08-25 | — | — | WO | disclosed |