Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 5/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.61 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.36 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.33 |
| ▸ | CDK2 | P24941 | 3/20 | 0.33 |
| ▸ | CCNA1 | P78396 | 3/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.32 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.32 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.32 |
| ▸ | CASR | P41180 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | CGAS | Q8N884 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4600390 | 1.00 | CYP3A4 (0.61) | CYP3A4CYP2C9RIPK1CCNA2CDK2 | |
| SCHEMBL4601224 | 1.00 | CYP3A4 (0.61) | CYP3A4CYP2C9RIPK1CCNA2CDK2 | |
| Dimethylamine SCHEMBL4613323 | 0.91 | CYP3A4 (0.62) | CYP3A4CYP2C9RIPK1KDM4ECASR | |
| SCHEMBL4600020 | 0.90 | CYP3A4 (0.59) | CYP3A4CYP2C9RIPK1CCNA2CDK2 | |
| SCHEMBL4602060 | 0.90 | CYP3A4 (0.59) | CYP3A4CYP2C9RIPK1CCNA2CDK2 | |
| SCHEMBL4600609 | 0.90 | CYP3A4 (0.59) | CYP3A4CYP2C9RIPK1CCNA2CDK2 | |
| SCHEMBL4600864 | 0.90 | CYP3A4 (0.65) | CYP3A4CYP2C9RIPK1KDM4EALDH1A1 | |
| SCHEMBL4599502 | 0.90 | CYP3A4 (0.65) | CYP3A4CYP2C9RIPK1KDM4EALDH1A1 | |
| SCHEMBL4599840 | 0.88 | CYP3A4 (0.63) | CYP3A4CYP2C9 | |
| SCHEMBL4601254 | 0.88 | CYP3A4 (0.63) | CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1718648-B1 | TRICYCLIC IMIDAZOPYRIDINES AND INTERMEDIATES FOR THE SYNTHESIS THEREOF | NYCOMED GMBH (DE) | 2008-04-23 | — | — | EP | claimed |
| EP-1718648-B1 | TRICYCLIC IMIDAZOPYRIDINES AND INTERMEDIATES FOR THE SYNTHESIS THEREOF | NYCOMED GMBH (DE) | 2008-04-23 | — | — | EP | disclosed |
| EP-1718648-A1 | TRICYCLIC IMIDAZOPYRIDINES AND INTERMEDIATES FOR THE SYNTHESIS THEREOF | Altana Pharma AG (DE) | 2006-11-08 | — | — | EP | disclosed |
| WO-2005077949-A1 | TRICYCLIC IMIDAZOPYRIDINES AND INTERMEDIATES FOR THE SYNTHESIS THEREOF | ALTANA PHARMA AG (DE) | 2005-08-25 | — | — | WO | disclosed |