Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 7/20 | 0.63 |
| ▸ | CYP2C9 | P11712 | 7/20 | 0.63 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 2/20 | 0.32 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.32 |
| ▸ | NOS1 | P29475 | 2/20 | 0.32 |
| ▸ | AKT1 | P31749 | 1/20 | 0.32 |
| ▸ | AKT2 | P31751 | 1/20 | 0.32 |
| ▸ | PDE4A | P27815 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.32 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.32 |
| ▸ | PARP3 | Q9Y6F1 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4599840 | 1.00 | CYP3A4 (0.63) | CYP3A4CYP2C9CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL4601741 | 1.00 | CYP3A4 (0.63) | CYP3A4CYP2C9CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL4599502 | 0.92 | CYP3A4 (0.65) | CYP3A4CYP2C9NOS1HSD17B10 | |
| SCHEMBL4600864 | 0.92 | CYP3A4 (0.65) | CYP3A4CYP2C9NOS1HSD17B10 | |
| SCHEMBL4613531 | 0.90 | CYP3A4 (0.61) | CYP3A4CYP2C9NOS1 | |
| Dimethylamine SCHEMBL4613323 | 0.89 | CYP3A4 (0.62) | CYP3A4CYP2C9TSHRNPSR1HSD17B10 | |
| SCHEMBL4601115 | 0.88 | CYP3A4 (0.61) | CYP3A4CYP2C9TSHRNPSR1HSD17B10 | |
| SCHEMBL4599597 | 0.88 | CYP3A4 (0.61) | CYP3A4CYP2C9 | |
| SCHEMBL4601558 | 0.88 | CYP3A4 (0.61) | CYP3A4CYP2C9TSHRNPSR1HSD17B10 | |
| SCHEMBL4601224 | 0.88 | CYP3A4 (0.61) | CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1718648-B1 | TRICYCLIC IMIDAZOPYRIDINES AND INTERMEDIATES FOR THE SYNTHESIS THEREOF | NYCOMED GMBH (DE) | 2008-04-23 | — | — | EP | disclosed |
| EP-1718648-A1 | TRICYCLIC IMIDAZOPYRIDINES AND INTERMEDIATES FOR THE SYNTHESIS THEREOF | Altana Pharma AG (DE) | 2006-11-08 | — | — | EP | disclosed |
| WO-2005077949-A1 | TRICYCLIC IMIDAZOPYRIDINES AND INTERMEDIATES FOR THE SYNTHESIS THEREOF | ALTANA PHARMA AG (DE) | 2005-08-25 | — | — | WO | disclosed |