SCHEMBL4599665

SCHEMBL4599665

COc1cc(CNC(=N)N)ccc1O

nearest known ligand 0.58

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
TAAR1 Q96RJ0 2/20 0.57
TSHR P16473 1/20 0.57
MAPK1 P28482 1/20 0.57
LMNA P02545 1/20 0.55
GLA P06280 1/20 0.55
ALDH1A1 P00352 3/20 0.54
CYP3A4 P08684 2/20 0.54
CYP1A2 P05177 1/20 0.54
CYP2D6 P10635 1/20 0.54
CYP2C9 P11712 1/20 0.54
HPGD P15428 1/20 0.54
ALOX15 P16050 1/20 0.54
CYP2C19 P33261 1/20 0.54
BLM P54132 1/20 0.54
PMP22 Q01453 1/20 0.54
ALOX5 P09917 1/20 0.54
AR P10275 1/20 0.54
PTGS1 P23219 1/20 0.54
TRPM8 Q7Z2W7 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1186351 0.89 ALDH1A1 (0.68) TSHRALDH1A1
SCHEMBL14520180 0.88 CYP1A2 (0.59) TSHRMAPK1LMNAALDH1A1CYP3A4
SCHEMBL24211767 0.86 TAAR1 (0.55) TAAR1TSHRMAPK1LMNAGLA
SCHEMBL4208734 0.84 ALDH1A1 (0.62) TAAR1TSHRMAPK1ALDH1A1CYP3A4
SCHEMBL29828592 0.84 PTPN7 (0.58) TAAR1TSHRMAPK1
SCHEMBL2846850 0.84 PTPN7 (0.58) TAAR1TSHRMAPK1
SCHEMBL10179935 0.83 ALDH1A1 (0.53) ALDH1A1
Hydrochloric Acid SCHEMBL3112626 0.82 ALDH1A1 (0.51) ALDH1A1
SCHEMBL8681333 0.82 ALDH1A1 (0.63) TSHRLMNAALDH1A1
SCHEMBL28464370 0.82 ALDH1A1 (0.59) TSHRALDH1A1CYP3A4CYP1A2CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1915063-A2 N-VANILLYL UREA DERIVATIVES AS FLAVOUR MODULATING SUBSTANCES Quest International Services B.V. (NL) 2008-04-30 EP claimed
WO-2007013811-A2 N-VANILLYL UREA DERIVATIVES AS FLAVOUR MODULATING SUBSTANCES QUEST INTERNATIONAL SERVICES B.V. (NL) 2007-02-01 WO claimed