SCHEMBL4599673

SCHEMBL4599673

O=C1OC2(c3ccc(O)cc3Oc3cc(O)ccc32)c2cc(CBr)ccc21

nearest known ligand 0.66

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FTO Q9C0B1 10/20 0.66
MAPT P10636 4/20 0.66
MEN1 O00255 3/20 0.66
KMT2A Q03164 3/20 0.66
HPGD P15428 2/20 0.66
HTT P42858 2/20 0.66
TDP1 Q9NUW8 2/20 0.66
CYP2C19 P33261 1/20 0.66
RECQL P46063 1/20 0.66
BLM P54132 1/20 0.66
SMAD3 P84022 1/20 0.66
PRMT1 Q99873 1/20 0.66
ACE2 Q9BYF1 1/20 0.66
ALDH1A1 P00352 3/20 0.47
ALOX12 P18054 2/20 0.47
ALOX15 P16050 2/20 0.47
HSD17B10 Q99714 2/20 0.47
CYP2C9 P11712 1/20 0.47
BRCA1 P38398 1/20 0.47
LMNA P02545 3/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29755003 0.91 FTO (0.67) FTOMAPTMEN1KMT2AHPGD
SCHEMBL337558 0.91 FTO (0.67) FTOMAPTMEN1KMT2AHPGD
SCHEMBL27584257 0.90 FTO (0.63) FTOMAPTMEN1KMT2AHPGD
SCHEMBL8813305 0.89 FTO (0.67) FTOMAPTMEN1KMT2AHPGD
SCHEMBL1949992 0.88 FTO (0.66) FTOMAPTMEN1KMT2AHPGD
SCHEMBL20438524 0.88 FTO (0.66) FTOMAPTMEN1KMT2AHPGD
SCHEMBL29496646 0.88 FTO (0.66) FTOMAPTMEN1KMT2AHPGD
SCHEMBL1539098 0.87 FTO (0.81) FTOMAPTMEN1KMT2AHPGD
Bromide SCHEMBL7792912 0.86 FTO (0.64) FTOMAPTMEN1KMT2AHPGD
Hydrochloric Acid SCHEMBL8542650 0.86 FTO (0.64) FTOMAPTMEN1KMT2AHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1238116-B1 PROCESS FOR LABELING A NUCLEIC ACID BIO MERIEUX (FR) 2008-04-16 EP claimed
US-6902891-B2 Process for labeling a nucleic acid BIO MERIEUX (FR) 2005-06-07 US claimed
EP-1238116-A1 PROCESS FOR LABELING A NUCLEIC ACID BIO MERIEUX (FR) 2002-09-11 EP claimed
US-20020081586-A1 Process for labeling a nucleic acid HOLOGIC, INC. 2002-06-27 US claimed
WO-2001044507-A1 PROCESS FOR LABELING A NUCLEIC ACID BIO MERIEUX (FR) 2001-06-21 WO claimed
EP-0919565-B2 Labeled oligonucleotides HOFFMANN LA ROCHE (CH) 2008-11-12 EP disclosed
US-7445900-B2 Homogeneous assay system ROCHE MOLECULAR SYSTEMS, INC. (US) 2008-11-04 US disclosed
US-20080171315-A1 Homogeneous assay system GELFAND DAVID H 2008-07-17 US disclosed
EP-1238116-B1 PROCESS FOR LABELING A NUCLEIC ACID BIO MERIEUX (FR) 2008-04-16 EP disclosed
EP-1302549-B1 Process for discriminating sequence variants HOFFMANN LA ROCHE (CH) 2007-06-27 EP disclosed
US-7141377-B2 Process for discrimination of nucleic acid sequence variants ROCHE MOLECULAR SYSTEMS, INC. (US) 2006-11-28 US disclosed
US-20060257885-A1 Homogeneous assay system GELFAND DAVID H 2006-11-16 US disclosed
EP-0919565-A2 Labeled oligonucleotides F. HOFFMANN-LA ROCHE AG (CH) 1999-06-02 EP disclosed
US-5804375-A PAIR OF NUCLEOTIDE PRIMERS AND LABELED OLIGONUCLEOTIDE ROCHE MOLECULAR SYSTEMS, INC. (US) 1998-09-08 US disclosed
EP-0537981-B1 Cleavage method for acyl thiohydantoins and use of the method in C-terminal peptide sequencing PERKIN ELMER CORP (US) 1998-06-03 EP disclosed
US-5487972-A POLYMERASE CHAIN REACTION AMPLIFICATION HOFFMANN-LA ROCHE INC. (US) 1996-01-30 US disclosed
EP-0543942-A1 HOMOGENEOUS ASSAY SYSTEM F. HOFFMANN-LA ROCHE AG (CH) 1993-06-02 EP disclosed
EP-0537981-A2 Cleavage method for acyl thiohydantoins and use of the method in C-terminal peptide sequencing THE PERKIN-ELMER CORPORATION (US) 1993-04-21 EP disclosed
US-5185266-A Cleaving an alkylated thiohydantoin adduct from a peptide under anhydrous, acidic conditions and analyzing the side chain of the amino acid APPLIED BIOSYSTEMS, INC. (US) 1993-02-09 US disclosed
WO-1992002638-A1 HOMOGENEOUS ASSAY SYSTEM F. HOFFMANN-LA ROCHE AG (CH) 1992-02-20 WO disclosed