Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FTO | Q9C0B1 | 10/20 | 0.64 |
| ▸ | MAPT | P10636 | 4/20 | 0.64 |
| ▸ | MEN1 | O00255 | 3/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.64 |
| ▸ | HPGD | P15428 | 2/20 | 0.64 |
| ▸ | HTT | P42858 | 2/20 | 0.64 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.64 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.64 |
| ▸ | RECQL | P46063 | 1/20 | 0.64 |
| ▸ | BLM | P54132 | 1/20 | 0.64 |
| ▸ | SMAD3 | P84022 | 1/20 | 0.64 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.64 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1949992 | 0.99 | FTO (0.66) | FTOMAPTMEN1KMT2AHPGD | |
| SCHEMBL29496646 | 0.99 | FTO (0.66) | FTOMAPTMEN1KMT2AHPGD | |
| Hydrochloric Acid SCHEMBL8542650 | 0.98 | FTO (0.64) | FTOMAPTMEN1KMT2AHPGD | |
| Bromide SCHEMBL6999393 | 0.91 | FTO (0.69) | FTOMAPTMEN1KMT2AHPGD | |
| SCHEMBL2334255 | 0.90 | FTO (0.70) | FTOMAPTMEN1KMT2AHPGD | |
| SCHEMBL30249984 | 0.90 | FTO (0.70) | FTOMAPTMEN1KMT2AHPGD | |
| Hydrochloric Acid SCHEMBL1904089 | 0.89 | FTO (0.69) | FTOMAPTMEN1KMT2AHPGD | |
| SCHEMBL8813305 | 0.88 | FTO (0.67) | FTOMAPTMEN1KMT2AHPGD | |
| SCHEMBL20438524 | 0.86 | FTO (0.66) | FTOMAPTMEN1KMT2AHPGD | |
| SCHEMBL4599673 | 0.86 | FTO (0.66) | FTOMAPTMEN1KMT2AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0712497-B1 | REAGENTS AND METHODS FOR THE DETECTION AND QUANTIFICATION OF TESTOSTERONE IN FLUID SAMPLES | ABBOTT LAB (US) | 2001-11-07 | — | — | EP | disclosed |
| US-5851781-A | Reagents and methods for the detection and quantification of testosterone in fluid samples | ABBOTT LABORATORIES (US) | 1998-12-22 | — | — | US | disclosed |
| US-5581002-A | BLOCKING WITH BUTYLDIMETHYLSILANYL CHLORIDE; ALKYLATION; OZONOLYZING WITH SODIUM HYPOCHLORITE; DEBLOCKING | ABBOTT LABORATORIES (US) | 1996-12-03 | — | — | US | disclosed |
| US-5559210-A | STEROIDS AS IMMUNOGENS | ABBOTT LABORATORIES (US) | 1996-09-24 | — | — | US | disclosed |
| EP-0712497-A1 | REAGENTS AND METHODS FOR THE DETECTION AND QUANTIFICATION OF TESTOSTERONE IN FLUID SAMPLES | Abbott Laboratories (US) | 1996-05-22 | — | — | EP | disclosed |
| US-5491071-A | LABELS; TEST KITS; IMMUNOASSAYS | ABBOTT LABORATORIES (US) | 1996-02-13 | — | — | US | disclosed |
| WO-1995004283-A1 | REAGENTS AND METHODS FOR THE DETECTION AND QUANTIFICATION OF TESTOSTERONE IN FLUID SAMPLES | ABBOTT LABORATORIES (US) | 1995-02-09 | — | — | WO | disclosed |