Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.63 |
| ▸ | MEN1 | O00255 | 2/20 | 0.63 |
| ▸ | TSHR | P16473 | 1/20 | 0.63 |
| ▸ | KCNK3 | O14649 | 2/20 | 0.61 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.59 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.59 |
| ▸ | HTT | P42858 | 1/20 | 0.59 |
| ▸ | RAB9A | P51151 | 1/20 | 0.59 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.57 |
| ▸ | AURKA | O14965 | 1/20 | 0.56 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.56 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.56 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.56 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.56 |
| ▸ | KCNQ5 | Q9NR82 | 1/20 | 0.56 |
| ▸ | LCK | P06239 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31435249 | 0.86 | MAPT (0.68) | MAPTKMT2AMEN1TSHRKCNK3 | |
| SCHEMBL15238350 | 0.86 | MAPT (0.68) | MAPTKMT2AMEN1TSHRKCNK3 | |
| SCHEMBL31435257 | 0.86 | MAPT (0.68) | MAPTKMT2AMEN1TSHRKCNK3 | |
| SCHEMBL23309685 | 0.85 | MAPT (0.71) | MAPTKMT2AMEN1TSHRKCNK3 | |
| SCHEMBL3486022 | 0.83 | RXFP1 (0.79) | MAPTKMT2AMEN1TSHRKCNK3 | |
| SCHEMBL4286068 | 0.83 | MAPT (0.94) | MAPTKMT2AMEN1TSHRKCNK3 | |
| SCHEMBL31435262 | 0.83 | MAPT (0.64) | MAPTKMT2AMEN1TSHRKCNK3 | |
| SCHEMBL4599730 | 0.82 | LMNA (0.62) | MAPTKMT2AMEN1KCNK3LMNA | |
| SCHEMBL24141032 | 0.81 | MAPT (0.84) | MAPTKMT2AMEN1TSHRKCNK3 | |
| SCHEMBL23447711 | 0.80 | MAPT (0.82) | MAPTKMT2AMEN1TSHRKCNK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1910295-A1 | SUBSTITUTED PYRIDOCARBOXAMIDES AS INHIBITORS OF PLASMINOGEN ACTIVATOR INHIBITOR 1 (PAI-1) | Bayer HealthCare AG (DE) | 2008-04-16 | — | — | EP | disclosed |
| WO-2007028456-A1 | SUBSTITUTED PYRIDOCARBOXAMIDES AS INHIBITORS OF PLASMINOGEN ACTIVATOR INHIBITOR 1 (PAI-1) | BAYER HEALTHCARE AG (DE) | 2007-03-15 | — | — | WO | disclosed |