Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.62 |
| ▸ | HTT | P42858 | 1/20 | 0.60 |
| ▸ | KCNK3 | O14649 | 3/20 | 0.54 |
| ▸ | NPC1 | O15118 | 5/20 | 0.54 |
| ▸ | RAB9A | P51151 | 5/20 | 0.54 |
| ▸ | MEN1 | O00255 | 4/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.53 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.53 |
| ▸ | JAK2 | O60674 | 1/20 | 0.51 |
| ▸ | TYK2 | P29597 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4599781 | 0.87 | MEN1 (0.63) | HTTNPC1RAB9AMEN1KMT2A | |
| SCHEMBL18027792 | 0.84 | RAB9A (0.68) | LMNANPC1RAB9AGAAHPGD | |
| SCHEMBL27485178 | 0.84 | JAK2 (0.60) | HTTKCNK3NPC1RAB9AMEN1 | |
| SCHEMBL11134265 | 0.82 | LMNA (0.64) | LMNAHTTKCNK3NPC1RAB9A | |
| SCHEMBL3369249 | 0.82 | LMNA (0.64) | LMNAHTTKCNK3NPC1RAB9A | |
| SCHEMBL16692727 | 0.82 | NPC1 (0.47) | LMNAHTTNPC1RAB9AMEN1 | |
| SCHEMBL4600071 | 0.82 | MAPT (0.70) | LMNAHTTKCNK3RAB9AMEN1 | |
| SCHEMBL23309670 | 0.81 | NPC1 (0.56) | HTTKCNK3NPC1RAB9AMEN1 | |
| SCHEMBL15238338 | 0.81 | LMNA (0.62) | LMNAHTTKCNK3NPC1RAB9A | |
| SCHEMBL15727556 | 0.81 | LMNA (0.67) | LMNAHTTKCNK3NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105579044-A | Use of dianhydrogalactitol and analogs and derivatives thereof for treating recurrent malignant glioma or progressive secondary brain tumor | DEL MAR PHARMACEUTICALS | 2016-05-11 | — | — | CN | disclosed |
| EP-1910295-A1 | SUBSTITUTED PYRIDOCARBOXAMIDES AS INHIBITORS OF PLASMINOGEN ACTIVATOR INHIBITOR 1 (PAI-1) | Bayer HealthCare AG (DE) | 2008-04-16 | — | — | EP | disclosed |
| WO-2007028456-A1 | SUBSTITUTED PYRIDOCARBOXAMIDES AS INHIBITORS OF PLASMINOGEN ACTIVATOR INHIBITOR 1 (PAI-1) | BAYER HEALTHCARE AG (DE) | 2007-03-15 | — | — | WO | disclosed |
| WO-2007028456-A1 | SUBSTITUTED PYRIDOCARBOXAMIDES AS INHIBITORS OF PLASMINOGEN ACTIVATOR INHIBITOR 1 (PAI-1) | BAYER HEALTHCARE AG (DE) | 2007-03-15 | — | — | WO | disclosed |