Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.66 |
| ▸ | GAA | P10253 | 3/20 | 0.66 |
| ▸ | MAPT | P10636 | 3/20 | 0.66 |
| ▸ | HPGD | P15428 | 3/20 | 0.66 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.66 |
| ▸ | NPC1 | O15118 | 8/20 | 0.54 |
| ▸ | RAB9A | P51151 | 7/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.46 |
| ▸ | HAVCR2 | Q8TDQ0 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.44 |
| ▸ | F2 | P00734 | 1/20 | 0.43 |
| ▸ | F10 | P00742 | 1/20 | 0.43 |
| ▸ | F7 | P08709 | 1/20 | 0.43 |
| ▸ | F3 | P13726 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13522986 | 0.81 | NPC1 (0.69) | KDM4EALDH1A1GAAMAPTHPGD | |
| SCHEMBL9646773 | 0.81 | KDM4E (1.00) | KDM4EALDH1A1GAAMAPTHPGD | |
| SCHEMBL220575 | 0.81 | KDM4E (0.68) | KDM4EALDH1A1GAAMAPTHPGD | |
| SCHEMBL9867464 | 0.81 | KDM4E (0.68) | KDM4EALDH1A1GAAMAPTHPGD | |
| SCHEMBL11645613 | 0.81 | KDM4E (0.68) | KDM4EALDH1A1GAAMAPTHPGD | |
| Iodide SCHEMBL11648822 | 0.79 | KDM4E (0.97) | KDM4EALDH1A1GAAMAPTHPGD | |
| Iodide SCHEMBL11648817 | 0.79 | KDM4E (0.97) | KDM4EALDH1A1GAAMAPTHPGD | |
| SCHEMBL26833315 | 0.79 | ALDH1A1 (1.00) | KDM4EALDH1A1GAAMAPTHPGD | |
| SCHEMBL11640732 | 0.77 | KDM4E (0.62) | KDM4EALDH1A1GAAMAPTHPGD | |
| SCHEMBL9868647 | 0.77 | KDM4E (0.62) | KDM4EALDH1A1GAAMAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1910384-A1 | IMIDAZO [2,1-B]THIAYOLE DERIVATIVES AS SIRTUIN MODULATING COMPOUNDS | Sirtris Pharmaceuticals, Inc. (US) | 2008-04-16 | — | — | EP | disclosed |
| WO-2007019344-A1 | IMIDAZO [2,1-B] THIAYOLE DERIVATIVES AS SIRTUIN MODULATING COMPOUNDS | SIRTRIS PHARMACEUTICALS, INC. (US) | 2007-02-15 | — | — | WO | disclosed |