Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TPSAB1 | Q15661 | 2/20 | 0.44 |
| ▸ | TPSD1 | Q9BZJ3 | 2/20 | 0.44 |
| ▸ | TPSG1 | Q9NRR2 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.41 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.40 |
| ▸ | ACE | P12821 | 1/20 | 0.40 |
| ▸ | CACNA1G | O43497 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | DRD2 | P14416 | 3/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2292771 | 1.00 | TPSAB1 (0.44) | TPSAB1TPSD1TPSG1KMT2AMEN1 | |
| SCHEMBL4599808 | 1.00 | TPSAB1 (0.44) | TPSAB1TPSD1TPSG1KMT2AMEN1 | |
| SCHEMBL4600478 | 0.99 | TPSAB1 (0.43) | TPSAB1TPSD1TPSG1KMT2AMEN1 | |
| SCHEMBL4600039 | 0.97 | KMT2A (0.47) | TPSAB1TPSD1TPSG1KMT2AMEN1 | |
| SCHEMBL1637220 | 0.97 | KMT2A (0.47) | TPSAB1TPSD1TPSG1KMT2AMEN1 | |
| SCHEMBL4599868 | 0.97 | KMT2A (0.47) | TPSAB1TPSD1TPSG1KMT2AMEN1 | |
| SCHEMBL4612508 | 0.93 | MALT1 (0.43) | TPSAB1TPSD1TPSG1KMT2AMEN1 | |
| SCHEMBL4717209 | 0.93 | MALT1 (0.43) | TPSAB1TPSD1TPSG1KMT2AMEN1 | |
| SCHEMBL9933024 | 0.92 | CXCR3 (0.45) | ALDH1A1 | |
| SCHEMBL4599020 | 0.87 | SYK (0.40) | KMT2AMEN1GAAMALT1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3423469-A1 | NEW TRIFLUOROMETHYLPROPANAMIDE DERIVATIVES AS HTRA1 INHIBITORS | H. Hoffnabb-La Roche Ag (CH) | 2019-01-09 | — | — | EP | disclosed |
| WO-2008080223-A1 | COMPOSITIONS AND METHODS FOR TREATING HYPERPROLIFERATIVE DISEASE | MIGENIX INC. (CA) | 2008-07-10 | — | — | WO | disclosed |
| EP-1910279-A2 | NON-NUCLEOSIDE ANTI-HEPACIVIRUS AGENTS AND USES THEREOF | MIGENIX INC. (CA) | 2008-04-16 | — | — | EP | disclosed |
| WO-2007002639-A2 | NON-NUCLEOSIDE ANTI-HEPACIVIRUS AGENTS AND USES THEREOF | MIGENIX INC. (CA) | 2007-01-04 | — | — | WO | disclosed |