Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.82 |
| ▸ | KDR | P35968 | 1/20 | 0.62 |
| ▸ | MITF | O75030 | 1/20 | 0.57 |
| ▸ | PPARG | P37231 | 1/20 | 0.55 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.55 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.55 |
| ▸ | PDE4A | P27815 | 1/20 | 0.53 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.53 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.53 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4599900 | 0.90 | KMT2A (0.70) | KMT2APPARGRXFP1NCOR2ALDH1A1 | |
| SCHEMBL4599856 | 0.89 | KMT2A (0.65) | KMT2APPARGRXFP1NCOR2 | |
| SCHEMBL10968907 | 0.84 | KMT2A (0.74) | KMT2AKDRPPARGRXFP1NCOR2 | |
| SCHEMBL10972052 | 0.82 | KMT2A (0.80) | KMT2AKDRALDH1A1 | |
| SCHEMBL10971106 | 0.82 | KMT2A (0.71) | KMT2AKDRPDE4APDE4BPDE4C | |
| SCHEMBL4939060 | 0.81 | KMT2A (0.82) | KMT2AKDRALDH1A1 | |
| SCHEMBL10972474 | 0.81 | KMT2A (0.70) | KMT2AKDR | |
| SCHEMBL2779361 | 0.81 | KMT2A (0.65) | KMT2AKDRPDE4APDE4BPDE4C | |
| SCHEMBL10971030 | 0.80 | KMT2A (0.75) | KMT2AKDRPPARGRXFP1NCOR2 | |
| SCHEMBL10968551 | 0.80 | KMT2A (0.75) | KMT2AKDRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1910295-A1 | SUBSTITUTED PYRIDOCARBOXAMIDES AS INHIBITORS OF PLASMINOGEN ACTIVATOR INHIBITOR 1 (PAI-1) | Bayer HealthCare AG (DE) | 2008-04-16 | — | — | EP | disclosed |
| WO-2007028456-A1 | SUBSTITUTED PYRIDOCARBOXAMIDES AS INHIBITORS OF PLASMINOGEN ACTIVATOR INHIBITOR 1 (PAI-1) | BAYER HEALTHCARE AG (DE) | 2007-03-15 | — | — | WO | disclosed |
| WO-2007028456-A1 | SUBSTITUTED PYRIDOCARBOXAMIDES AS INHIBITORS OF PLASMINOGEN ACTIVATOR INHIBITOR 1 (PAI-1) | BAYER HEALTHCARE AG (DE) | 2007-03-15 | — | — | WO | disclosed |