Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.60 |
| ▸ | PPARG | P37231 | 1/20 | 0.56 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.56 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.56 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | RECQL | P46063 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | PRKCI | P41743 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4939060 | 0.91 | KMT2A (0.82) | KMT2AALDH1A1MAPK8TDP1GAA | |
| SCHEMBL4600567 | 0.90 | KMT2A (0.82) | KMT2AALDH1A1PPARGRXFP1NCOR2 | |
| SCHEMBL4599856 | 0.88 | KMT2A (0.65) | KMT2APPARGRXFP1NCOR2NPC1 | |
| SCHEMBL11810048 | 0.83 | PDE10A (0.60) | KMT2AALDH1A1MAPK8TDP1RAB9A | |
| SCHEMBL2485533 | 0.83 | KMT2A (0.67) | KMT2A | |
| SCHEMBL6120093 | 0.80 | RAB9A (0.72) | ALDH1A1MAPK8TDP1RAB9AGAA | |
| SCHEMBL10973818 | 0.79 | KMT2A (0.68) | KMT2AALDH1A1PPARGRXFP1NCOR2 | |
| SCHEMBL10971064 | 0.79 | ALDH1A1 (0.72) | KMT2AALDH1A1MAPK8TDP1NPC1 | |
| SCHEMBL7906081 | 0.79 | PDE10A (0.67) | KMT2AALDH1A1TDP1 | |
| SCHEMBL14284685 | 0.77 | PNLIP (0.68) | KMT2AALDH1A1TDP1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1910295-A1 | SUBSTITUTED PYRIDOCARBOXAMIDES AS INHIBITORS OF PLASMINOGEN ACTIVATOR INHIBITOR 1 (PAI-1) | Bayer HealthCare AG (DE) | 2008-04-16 | — | — | EP | disclosed |
| WO-2007028456-A1 | SUBSTITUTED PYRIDOCARBOXAMIDES AS INHIBITORS OF PLASMINOGEN ACTIVATOR INHIBITOR 1 (PAI-1) | BAYER HEALTHCARE AG (DE) | 2007-03-15 | — | — | WO | disclosed |