Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ATP4A | P20648 | 3/20 | 0.40 |
| ▸ | ATP4B | P51164 | 3/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.35 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.34 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | AKT1 | P31749 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4600669 | 1.00 | ALDH1A1 (0.45) | ALDH1A1KDM4EATP4AATP4BCYP3A4 | |
| SCHEMBL4600310 | 0.93 | ALDH1A1 (0.46) | ALDH1A1KDM4EATP4AATP4BCYP3A4 | |
| SCHEMBL4600316 | 0.93 | ALDH1A1 (0.46) | ALDH1A1KDM4EATP4AATP4BCYP3A4 | |
| SCHEMBL4600666 | 0.89 | ALDH1A1 (0.43) | ALDH1A1KDM4EATP4AATP4BCYP3A4 | |
| SCHEMBL4601572 | 0.89 | ALDH1A1 (0.43) | ALDH1A1KDM4EATP4AATP4BCYP3A4 | |
| SCHEMBL4601062 | 0.89 | ALDH1A1 (0.43) | ALDH1A1KDM4EATP4AATP4BCYP1A2 | |
| SCHEMBL4601067 | 0.89 | ALDH1A1 (0.43) | ALDH1A1KDM4EATP4AATP4BCYP1A2 | |
| SCHEMBL4600661 | 0.89 | ALDH1A1 (0.43) | ALDH1A1KDM4EATP4AATP4BCYP3A4 | |
| SCHEMBL4601568 | 0.89 | ALDH1A1 (0.43) | ALDH1A1KDM4EATP4AATP4BCYP3A4 | |
| Hydrochloric Acid SCHEMBL4600903 | 0.85 | ALDH1A1 (0.40) | ALDH1A1KDM4EATP4AATP4BCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1718648-B1 | TRICYCLIC IMIDAZOPYRIDINES AND INTERMEDIATES FOR THE SYNTHESIS THEREOF | NYCOMED GMBH (DE) | 2008-04-23 | — | — | EP | disclosed |
| EP-1718648-A1 | TRICYCLIC IMIDAZOPYRIDINES AND INTERMEDIATES FOR THE SYNTHESIS THEREOF | Altana Pharma AG (DE) | 2006-11-08 | — | — | EP | disclosed |
| WO-2005077949-A1 | TRICYCLIC IMIDAZOPYRIDINES AND INTERMEDIATES FOR THE SYNTHESIS THEREOF | ALTANA PHARMA AG (DE) | 2005-08-25 | — | — | WO | disclosed |