Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 5/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 4/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA7 | P43166 | 1/20 | 0.40 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | F2 | P00734 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2932348 | 0.93 | HTT (0.46) | POLBCYP3A4HTTMAPTKDM4E | |
| SCHEMBL6755855 | 0.90 | HTT (0.47) | POLBCYP3A4HTTMAPTKDM4E | |
| SCHEMBL27603447 | 0.88 | MAPT (0.45) | POLBCYP3A4HTTMAPTKDM4E | |
| SCHEMBL1026866 | 0.88 | KDM4E (0.45) | POLBCYP3A4HTTMAPTKDM4E | |
| SCHEMBL8919318 | 0.88 | HTT (0.44) | POLBCYP3A4HTTMAPTKDM4E | |
| SCHEMBL8920097 | 0.86 | CYP3A4 (0.44) | POLBCYP3A4HTTMAPTKDM4E | |
| SCHEMBL5386521 | 0.85 | POLB (0.40) | POLBCYP3A4HTTMAPTKDM4E | |
| SCHEMBL5416063 | 0.85 | KDM4E (0.43) | POLBCYP3A4HTTMAPTKDM4E | |
| SCHEMBL6755732 | 0.84 | MAPT (0.42) | POLBCYP3A4HTTMAPTKDM4E | |
| SCHEMBL5399448 | 0.84 | CYP3A4 (0.43) | POLBCYP3A4HTTMAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101287710-A | Preparation of 4, 5-diamino-1- (substituted) pyrazoles and their acid addition salts | EASTMAN CHEM CO (US) | 2008-10-15 | — | — | CN | disclosed |
| EP-1912950-A2 | PREPARATION OF 4,5-DIAMINO-1-(SUBSTITUTED)-PYRAZOLE AND ACID ADDITION SALTS THEREOF | EASTMAN CHEMICAL COMPANY (US) | 2008-04-23 | — | — | EP | disclosed |
| WO-2007021873-A2 | PREPARATION OF 4,5-DIAMINO-1-(SUBSTITUTED)-PYRAZOLE AND ACID ADDITION SALTS THEREOF | EASTMAN CHEMICAL COMPANY (US) | 2007-02-22 | — | — | WO | disclosed |
| US-20070037987-A1 | Preparation of 4,5-diamino-1-(substituted)-pyrazole and acid addition salts thereof | EASTMAN CHEMICAL COMPANY | 2007-02-15 | — | — | US | disclosed |
| EP-1342716-A2 | Preparation of 4,5-diamino-1-(2'-hydroxyethyl)-pyradazole and acid addition salts thereof | EASTMAN CHEMICAL COMPANY (US) | 2003-09-10 | — | — | EP | disclosed |
| US-6452019-B1 | SIMPLIFIED PROCESS THAT DOES NOT INVOLVE TOXIC SOLVENTS NOR MULTIPLE ISOLATIONS OF INTERMEDIATE PRODUCTS; CYCLIZATION OF ALKYL(ETHOXYMETHYLENE)CYANOACETATE AND 2-HYDROXY-ETHYL-HYDRAZINE; DECARBOXYLATING; NITROSATION TO AMINATE | EASTMAN CHEMICAL COMPANY | 2002-09-17 | — | — | US | disclosed |
| US-5663366-A | Process for the synthesis of 4,5-diaminopyrazole derivatives useful for dyeing hair | WELLA AKTIENGESELLSCHAT (DE) | 1997-09-02 | — | — | US | disclosed |
| EP-0618902-A1 | PROCESS FOR PRODUCING 4,5-DIAMINO PYRAZOLE DERIVATIVES, THEIR USE FOR COLOURING HAIR AND NOVEL PYRAZOLE DERIVATIVES | Wella Aktiengesellschaft (DE) | 1994-10-12 | — | — | EP | disclosed |
| WO-1994008969-A1 | PROCESS FOR PRODUCING 4,5-DIAMINO PYRAZOLE DERIVATIVES, THEIR USE FOR COLOURING HAIR AND NOVEL PYRAZOLE DERIVATIVES | WELLA AKTIENGESELLSCHAFT (DE) | 1994-04-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070037987-A1 | Preparation of 4,5-diamino-1-(substituted)-pyrazole and acid addition salts thereof | DDC, DAO, IL4I1 | POLB 2020/4885CYP3A4 19/4885HTT 2849/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.