Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 5/20 | 0.57 |
| ▸ | ROCK1 | Q13464 | 5/20 | 0.57 |
| ▸ | PPARG | P37231 | 1/20 | 0.57 |
| ▸ | CNR2 | P34972 | 2/20 | 0.53 |
| ▸ | EGFR | P00533 | 1/20 | 0.53 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | DRD2 | P14416 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4601231 | 0.87 | PPARG (0.55) | ROCK2ROCK1PPARGCNR2EGFR | |
| SCHEMBL3461102 | 0.80 | NPC1 (0.70) | PPARGHTTMEN1HCRTR1KMT2A | |
| SCHEMBL13947495 | 0.79 | NPC1 (0.61) | HTTMEN1HCRTR1KMT2AALDH1A1 | |
| SCHEMBL30462959 | 0.79 | NPC1 (0.61) | HTTMEN1HCRTR1KMT2AALDH1A1 | |
| SCHEMBL10318179 | 0.79 | NPC1 (0.55) | ROCK2ROCK1MEN1HCRTR1KMT2A | |
| SCHEMBL5332860 | 0.79 | NPC1 (0.72) | PLA2G1BATG4BMEN1KMT2AHPGD | |
| SCHEMBL2912888 | 0.78 | MAPK1 (0.55) | ROCK2ROCK1PPARGNPC1 | |
| SCHEMBL27909695 | 0.78 | NPC1 (0.71) | PPARGHTTMEN1KMT2AALDH1A1 | |
| SCHEMBL10318178 | 0.77 | NPC1 (0.53) | ROCK2ROCK1PPARGMEN1HCRTR1 | |
| SCHEMBL4074391 | 0.77 | HDAC1 (0.56) | ROCK2ROCK1PPARGALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1940786-A1 | BIPHENYL DERIVATIVES AND THEIR USE IN TREATING HEPATITIS C | Arrow Therapeutics Limited (GB) | 2008-07-09 | — | — | EP | disclosed |
| WO-2007031791-A1 | BIPHENYL DERIVATIVES AND THEIR USE IN TREATING HEPATITIS C | ARROW THERAPEUTICS LIMITED (GB) | 2007-03-22 | — | — | WO | disclosed |