Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 2/20 | 0.56 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.51 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.51 |
| ▸ | PARP1 | P09874 | 1/20 | 0.43 |
| ▸ | VNN1 | O95497 | 1/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
| ▸ | SHMT1 | P34896 | 1/20 | 0.42 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.42 |
| ▸ | CD38 | P28907 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | PLAU | P00749 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4487434 | 0.88 | SMN1; SMN2 (0.50) | HDAC1ADRB1ADRB3PPARGALDH1A1 | |
| SCHEMBL4486859 | 0.86 | OPRM1 (0.52) | PARP1GPR52ROCK2 | |
| SCHEMBL1348877 | 0.82 | HDAC1 (0.59) | HDAC1ADRB3PARP1VNN1CHRM2 | |
| Hydrochloric Acid SCHEMBL3340188 | 0.81 | HDAC1 (0.57) | HDAC1ADRB3PARP1VNN1CHRM2 | |
| SCHEMBL4074968 | 0.81 | OPRM1 (0.60) | HDAC1ADRB1ADRB3ALDH1A1ROCK1 | |
| SCHEMBL2909884 | 0.81 | HDAC1 (0.57) | HDAC1ADRB1ADRB3PPARGALDH1A1 | |
| SCHEMBL2912073 | 0.79 | HDAC1 (0.55) | HDAC1ADRB1ADRB3PPARGALDH1A1 | |
| SCHEMBL4073993 | 0.79 | SCN3A (0.42) | HDAC1ALDH1A1 | |
| SCHEMBL4081861 | 0.79 | OPRM1 (0.53) | HDAC1ADRB1ADRB3ROCK1 | |
| SCHEMBL4073644 | 0.77 | OPRM1 (0.53) | HDAC1ADRB1ADRB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7615651-B2 | Diaryl, dipyridinyl and aryl-pyridinyl derivatives and uses thereof | PFIZER INC. (US) | 2009-11-10 | — | — | US | claimed |
| EP-2084127-A1 | DIARYL, DIPYRIDINYL AND ARYL-PYRIDINYL DERIVATIVES AND USES THEREOF | Pfizer Products Inc. (US) | 2009-08-05 | — | — | EP | claimed |
| WO-2008059335-A1 | DIARYL, DIPYRIDINYL AND ARYL-PYRIDINYL DERIVATIVES AND USES THEREOF | PFIZER PRODUCTS INC. (US) | 2008-05-22 | — | — | WO | claimed |